SCOPe 2.08: Structural Classification of Proteins

PDB entry 3wn5

View 3wn5 on RCSB PDB site
Description: Crystal structure of asymmetrically engineered Fc variant in complex with FcgRIIIa
Class: immune system
Keywords: receptor complex, fc receptor, antibody, immune system
Deposited on 2013-12-05, released 2014-11-19
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 2.78 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: Ig gamma-1 chain C region
Species: Homo sapiens [TaxId:9606]
Gene: IGHG1
Database cross-references and differences (RAF-indexed):
- Uniprot P01857
  - engineered mutation (54)
  - engineered mutation (110)
  - engineered mutation (114)
  - engineered mutation (118)
  - engineered mutation (140)
  - engineered mutation (150)
  - engineered mutation (152)
  - engineered mutation (191)
Domains in SCOPe 2.08: d3wn5a1, d3wn5a2
Chain 'B':
Compound: Ig gamma-1 chain C region
Species: Homo sapiens [TaxId:9606]
Gene: IGHG1
Database cross-references and differences (RAF-indexed):
- Uniprot P01857
  - engineered mutation (19-20)
  - engineered mutation (23)
  - engineered mutation (52)
  - engineered mutation (82)
  - engineered mutation (111)
  - engineered mutation (133)
  - engineered mutation (150)
Domains in SCOPe 2.08: d3wn5b1, d3wn5b2
Chain 'C':
Compound: Low affinity immunoglobulin gamma Fc region receptor III-A
Species: Homo sapiens [TaxId:9606]
Gene: FCGR3A, CD16A, FCG3, FCGR3, IGFR3
Database cross-references and differences (RAF-indexed):
- Uniprot P08637
  - engineered mutation (38)
  - engineered mutation (74)
  - see remark 999 (158)
  - engineered mutation (169)
Domains in SCOPe 2.08: d3wn5c1, d3wn5c2
Chain 'D':
Compound: Ig gamma-1 chain C region
Species: Homo sapiens [TaxId:9606]
Gene: IGHG1
Database cross-references and differences (RAF-indexed):
- Uniprot P01857
  - engineered mutation (54)
  - engineered mutation (110)
  - engineered mutation (114)
  - engineered mutation (118)
  - engineered mutation (140)
  - engineered mutation (150)
  - engineered mutation (152)
  - engineered mutation (191)
Domains in SCOPe 2.08: d3wn5d1, d3wn5d2
Chain 'E':
Compound: Ig gamma-1 chain C region
Species: Homo sapiens [TaxId:9606]
Gene: IGHG1
Database cross-references and differences (RAF-indexed):
- Uniprot P01857
  - engineered mutation (19-20)
  - engineered mutation (23)
  - engineered mutation (52)
  - engineered mutation (82)
  - engineered mutation (111)
  - engineered mutation (133)
  - engineered mutation (150)
Domains in SCOPe 2.08: d3wn5e1, d3wn5e2
Chain 'F':
Compound: Low affinity immunoglobulin gamma Fc region receptor III-A
Species: Homo sapiens [TaxId:9606]
Gene: FCGR3A, CD16A, FCG3, FCGR3, IGFR3
Database cross-references and differences (RAF-indexed):
- Uniprot P08637
  - engineered mutation (38)
  - engineered mutation (74)
  - see remark 999 (158)
  - engineered mutation (169)
Domains in SCOPe 2.08: d3wn5f1, d3wn5f2
Heterogens: IOD, NAG, HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>3wn5A (A:)
epkssdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvsheepevkf
nwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsndalpkpieet
iskakgqprepqvytlppsrceltknqvslscavkgfypsdiavewesngqpennykttp
pvldsdgsfflvskltvdksrwqqgnvfscsvmhealhnhytqkslslsp