PDB entry 3wjj

View 3wjj on RCSB PDB site
Description: Crystal structure of IIb selective Fc variant, Fc(P238D), in complex with FcgRIIb
Class: immune system
Keywords: receptor complex, fc receptor, antibody, immune system
Deposited on 2013-10-10, released 2013-11-13
The last revision prior to the SCOPe 2.06 freeze date was dated 2014-11-26, with a file datestamp of 2014-11-21.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.232
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Ig gamma-1 chain C region
    Species: Homo sapiens [TaxId:9606]
    Gene: IGHG1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01857
      • engineered mutation (22)
    Domains in SCOPe 2.06: d3wjja1, d3wjja2
  • Chain 'B':
    Compound: Ig gamma-1 chain C region
    Species: Homo sapiens [TaxId:9606]
    Gene: IGHG1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01857
      • engineered mutation (22)
    Domains in SCOPe 2.06: d3wjjb1, d3wjjb2
  • Chain 'C':
    Compound: Low affinity immunoglobulin gamma Fc region receptor II-b
    Species: Homo sapiens [TaxId:9606]
    Gene: CD32, FCG2, FCGR2B, FCGR2C, IGFR2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3wjjc1, d3wjjc2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3wjjA (A:)
    epkssdkthtcppcpapellggdsvflfppkpkdtlmisrtpevtcvvvdvshedpevkf
    nwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiekt
    iskakgqprepqvytlppsrdeltknqvsltclvkgfypsdiavewesngqpennykttp
    pvldsdgsfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslsp
    

    Sequence, based on observed residues (ATOM records): (download)
    >3wjjA (A:)
    ellggdsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpr
    eeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqprepqvytlp
    psrdeltknqvsltclvkgfypsdiavewesngqpennykttppvldsdgsfflyskltv
    dksrwqqgnvfscsvmhealhnhytqkslsls
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >3wjjB (B:)
    epkssdkthtcppcpapellggdsvflfppkpkdtlmisrtpevtcvvvdvshedpevkf
    nwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiekt
    iskakgqprepqvytlppsrdeltknqvsltclvkgfypsdiavewesngqpennykttp
    pvldsdgsfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslsp
    

    Sequence, based on observed residues (ATOM records): (download)
    >3wjjB (B:)
    dsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeqyn
    styrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqprepqvytlppsrde
    ltknqvsltclvkgfypsdiavewesngqpennykttppvldsdgsfflyskltvdksrw
    qqgnvfscsvmhealhnhytqkslsl
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >3wjjC (C:)
    aappkavlklepqwinvlqedsvtltcrgthspesdsiqwfhngnlipthtqpsyrfkan
    nndsgeytcqtgqtslsdpvhltvlsewlvlqtphlefqegetivlrchswkdkplvkvt
    ffqngkskkfsrsdpnfsipqanhshsgdyhctgnigytlysskpvtitvqaphhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >3wjjC (C:)
    avlklepqwinvlqedsvtltcrgthspesdsiqwfhngnlipthtqpsyrfkannndsg
    eytcqtgqtslsdpvhltvlsewlvlqtphlefqegetivlrchswkdkplvkvtffqng
    kskkfsrsdpnfsipqanhshsgdyhctgnigytlysskpvtit