PDB entry 3wf9

View 3wf9 on RCSB PDB site
Description: Crystal structure of S6K1 kinase domain in complex with a quinoline derivative 1-oxo-1-[(4-sulfamoylphenyl)amino]propan-2-yl-2-methyl-1,2,3,4-tetrahydroacridine-9-carboxylate
Class: transferase/transferase inhibitor
Keywords: SERINE/THREONINE PROTEIN KINASE DOMAIN, TRANSFERASE, PHOSPHORYLATION, ATP-BINDING, ZINC-BINDING, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2013-07-17, released 2014-08-06
The last revision prior to the SCOPe 2.05 freeze date was dated 2014-10-29, with a file datestamp of 2014-10-24.
Experiment type: XRAY
Resolution: 2.04 Å
R-factor: 0.217
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Ribosomal protein S6 kinase beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: RPS6KB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d3wf9a_
  • Heterogens: ZN, FS7, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3wf9A (A:)
gsftssgsvnrgpekirpecfellrvlgkggygkvfqvrkvtgantgkifamkvlkkami
vrnakdtahtkaernileevkhpfivdliyafqtggklylileylsggelfmqleregif
medtacfylaeismalghlhqkgiiyrdlkpenimlnhqghvkltdfglckesihdgtvt
htfcgtieymapeilmrsghnravdwwslgalmydmltgappftgenrkktidkilkckl
nlppyltqeardllkkllkrnaasrlgagpgdagevqahpffrhinweellarkveppfk
pllqseedvsqfdskftrqtpvdspddst

    Sequence, based on observed residues (ATOM records): (download) 
    >3wf9A (A:)
kirpecfellrvlgkggygkvfqvrkvtgantgkifamkvlkkamivrnakdtahtkaer
nileevkhpfivdliyafqtggklylileylsggelfmqleregifmedtacfylaeism
alghlhqkgiiyrdlkpenimlnhqghvkltdfglckesihdgtvthtfcgtieymapei
lmrsghnravdwwslgalmydmltgappftgenrkktidkilkcklnlppyltqeardll
kkllkrnaasrlgagpgdagevqahpffrhinweellarkveppfkpl