PDB entry 3wf6

View 3wf6 on RCSB PDB site
Description: Crystal structure of S6K1 kinase domain in complex with a pyrazolopyrimidine derivative 4-[4-(1H-indol-3-yl)-3,6-dihydropyridin-1(2H)-yl]-1H-pyrazolo[3,4-d]pyrimidine
Class: transferase/transferase inhibitor
Keywords: SERINE/THREONINE PROTEIN KINASE DOMAIN, TRANSFERASE, PHOSPHORYLATION, ATP-BINDING, ZINC-BINDING, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2013-07-17, released 2014-08-06
The last revision prior to the SCOPe 2.07 freeze date was dated 2014-10-29, with a file datestamp of 2014-10-24.
Experiment type: XRAY
Resolution: 2.03 Å
R-factor: 0.198
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Ribosomal protein S6 kinase beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: RPS6KB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3wf6a_
  • Heterogens: ZN, FZ9, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3wf6A (A:)
gsftssgsvnrgpekirpecfellrvlgkggygkvfqvrkvtgantgkifamkvlkkami
vrnakdtahtkaernileevkhpfivdliyafqtggklylileylsggelfmqleregif
medtacfylaeismalghlhqkgiiyrdlkpenimlnhqghvkltdfglckesihdgtvt
htfcgtieymapeilmrsghnravdwwslgalmydmltgappftgenrkktidkilkckl
nlppyltqeardllkkllkrnaasrlgagpgdagevqahpffrhinweellarkveppfk
pllqseedvsqfdskftrqtpvdspddst

    Sequence, based on observed residues (ATOM records): (download) 
    >3wf6A (A:)
kirpecfellrvlgkggygkvfqvrkvtgantgkifamkvlkktkaernileevkhpfiv
dliyafqtggklylileylsggelfmqleregifmedtacfylaeismalghlhqkgiiy
rdlkpenimlnhqghvkltdfglckesihdgtvthtfcgtieymapeilmrsghnravdw
wslgalmydmltgappftgenrkktidkilkcklnlppyltqeardllkkllkrnaasrl
gagpgdagevqahpffrhinweellarkveppfkpllq