PDB entry 3wej

View 3wej on RCSB PDB site
Description: Crystal structure of the human squalene synthase F288A mutant in complex with presqualene pyrophosphate
Class: transferase
Keywords: Farnesyl-diphosphate farnesyltransferase, Head-to-head synthases, Cholesterol biosynthesis, Oxidoreductase, Transferase
Deposited on 2013-07-07, released 2014-02-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-25, with a file datestamp of 2019-12-20.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Squalene synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: FDFT1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P37268
      • engineered mutation (260)
    Domains in SCOPe 2.08: d3weja_
  • Heterogens: MG, PS7, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3wejA (A:)
    gshmdqdslssslktcykylnqtsrsfaaviqaldgemrnavcifylvlraldtleddmt
    isvekkvpllhnfhsflyqpdwrfmeskekdrqvledfptislefrnlaekyqtviadic
    rrmgigmaefldkhvtseqewdkychyvaglvgiglsrlfsasefedplvgedteransm
    glflqktniirdyledqqggrefwpqevwsryvkklgdfakpenidlavqclnelitnal
    hhipdvitylsrlrnqsvfnacaipqvmaiatlaacynnqqvfkgavkirkgqavtlmmd
    atnmpavkaiiyqymeeiyhripdsdpsssktrqiistirtqn
    

    Sequence, based on observed residues (ATOM records): (download)
    >3wejA (A:)
    slssslktcykylnqtsrsfaaviqaldgemrnavcifylvlraldtleddmtisvekkv
    pllhnfhsflyqpdwrfmeskekdrqvledfptislefrnlaekyqtviadicrrmgigm
    aefldkhvtseqewdkychyvaglvgiglsrlfsasefedplvgedteransmglflqkt
    niirdyledqqggrefwpqevwsryvkklgdfakpenidlavqclnelitnalhhipdvi
    tylsrlrnqsvfnacaipqvmaiatlaacynnqqvfkgavkirkgqavtlmmdatnmpav
    kaiiyqymeeiyhripdsdpsssktrqiistirtq