PDB entry 3wef

View 3wef on RCSB PDB site
Description: Crystal structure of the human squalene synthase in complex with farnesyl thiopyrophosphate
Class: transferase
Keywords: Farnesyl-diphosphate farnesyltransferase, Head-to-head synthases, Cholesterol biosynthesis, Oxidoreductase, Transferase
Deposited on 2013-07-07, released 2014-02-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-25, with a file datestamp of 2019-12-20.
Experiment type: XRAY
Resolution: 2.35 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Squalene synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: FDFT1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3wefa_
  • Chain 'B':
    Compound: Squalene synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: FDFT1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3wefb_
  • Chain 'C':
    Compound: Squalene synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: FDFT1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3wefc_
  • Chain 'D':
    Compound: Squalene synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: FDFT1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3wefd_
  • Chain 'E':
    Compound: Squalene synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: FDFT1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3wefe_
  • Chain 'F':
    Compound: Squalene synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: FDFT1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3weff_
  • Heterogens: FPS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3wefA (A:)
    gshmdqdslssslktcykylnqtsrsfaaviqaldgemrnavcifylvlraldtleddmt
    isvekkvpllhnfhsflyqpdwrfmeskekdrqvledfptislefrnlaekyqtviadic
    rrmgigmaefldkhvtseqewdkychyvaglvgiglsrlfsasefedplvgedteransm
    glflqktniirdyledqqggrefwpqevwsryvkklgdfakpenidlavqclnelitnal
    hhipdvitylsrlrnqsvfnfcaipqvmaiatlaacynnqqvfkgavkirkgqavtlmmd
    atnmpavkaiiyqymeeiyhripdsdpsssktrqiistirtqn
    

    Sequence, based on observed residues (ATOM records): (download)
    >3wefA (A:)
    lssslktcykylnqtsrsfaaviqaldgemrnavcifylvlraldtleddmtisvekkvp
    llhnfhsflyqpdwrfmeskekdrqvledfptislefrnlaekyqtviadicrrmgigma
    efldkhvtseqewdkychyvaglvgiglsrlfsasefedplvgedteransmglflqktn
    iirdyledqqggrefwpqevwsryvkklgdfakpenidlavqclnelitnalhhipdvit
    ylsrlrnqsvfnfcaipqvmaiatlaacynnqqvfkgavkirmmdatnmpavkaiiyqym
    eeiyhripdsdpsssktrqiistirtq
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >3wefB (B:)
    gshmdqdslssslktcykylnqtsrsfaaviqaldgemrnavcifylvlraldtleddmt
    isvekkvpllhnfhsflyqpdwrfmeskekdrqvledfptislefrnlaekyqtviadic
    rrmgigmaefldkhvtseqewdkychyvaglvgiglsrlfsasefedplvgedteransm
    glflqktniirdyledqqggrefwpqevwsryvkklgdfakpenidlavqclnelitnal
    hhipdvitylsrlrnqsvfnfcaipqvmaiatlaacynnqqvfkgavkirkgqavtlmmd
    atnmpavkaiiyqymeeiyhripdsdpsssktrqiistirtqn
    

    Sequence, based on observed residues (ATOM records): (download)
    >3wefB (B:)
    ssslktcykylnqtsrsfaaviqaldgemrnavcifylvlraldtleddmtisvekkvpl
    lhnfhsflyqpdwrfmeskekdrqvledfptislefrnlaekyqtviadicrrmgigmae
    fldkhvtseqewdkychyvaglvgiglsrlfsasefedplvgedteransmglflqktni
    irdyledqqggrefwpqevwsryvkklgdfakpenidlavqclnelitnalhhipdvity
    lsrlrnqsvfnfcaipqvmaiatlaacynnqqvfkgavkirkgqavtlmmdatnmpavka
    iiyqymeeiyhripdsdpsssktrqiistirtq
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >3wefC (C:)
    gshmdqdslssslktcykylnqtsrsfaaviqaldgemrnavcifylvlraldtleddmt
    isvekkvpllhnfhsflyqpdwrfmeskekdrqvledfptislefrnlaekyqtviadic
    rrmgigmaefldkhvtseqewdkychyvaglvgiglsrlfsasefedplvgedteransm
    glflqktniirdyledqqggrefwpqevwsryvkklgdfakpenidlavqclnelitnal
    hhipdvitylsrlrnqsvfnfcaipqvmaiatlaacynnqqvfkgavkirkgqavtlmmd
    atnmpavkaiiyqymeeiyhripdsdpsssktrqiistirtqn
    

    Sequence, based on observed residues (ATOM records): (download)
    >3wefC (C:)
    lssslktcykylnqtsrsfaaviqaldgemrnavcifylvlraldtleddmtisvekkvp
    llhnfhsflyqpdwrfmeskekdrqvledfptislefrnlaekyqtviadicrrmgigma
    efldkhvtseqewdkychyvaglvgiglsrlfsasefedplvgedteransmglflqktn
    iirdyledqqggrefwpqevwsryvkklgdfakpenidlavqclnelitnalhhipdvit
    ylsrlrnqsvfnfcaipqvmaiatlaacynnqqvfkgavkirkgqavtlmmdatnmpavk
    aiiyqymeeiyhripdsdpsssktrqiistirt
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >3wefD (D:)
    gshmdqdslssslktcykylnqtsrsfaaviqaldgemrnavcifylvlraldtleddmt
    isvekkvpllhnfhsflyqpdwrfmeskekdrqvledfptislefrnlaekyqtviadic
    rrmgigmaefldkhvtseqewdkychyvaglvgiglsrlfsasefedplvgedteransm
    glflqktniirdyledqqggrefwpqevwsryvkklgdfakpenidlavqclnelitnal
    hhipdvitylsrlrnqsvfnfcaipqvmaiatlaacynnqqvfkgavkirkgqavtlmmd
    atnmpavkaiiyqymeeiyhripdsdpsssktrqiistirtqn
    

    Sequence, based on observed residues (ATOM records): (download)
    >3wefD (D:)
    ssslktcykylnqtsrsfaaviqaldgemrnavcifylvlraldtleddmtisvekkvpl
    lhnfhsflyqpdwrfmeskekdrqvledfptislefrnlaekyqtviadicrrmgigmae
    fldkhvtseqewdkychyvaglvgiglsrlfsasefedplvgedteransmglflqktni
    irdyledqqggrefwpqevwsryvkklgdfakpenidlavqclnelitnalhhipdvity
    lsrlrnqsvfnfcaipqvmaiatlaacynnqqvfkgavkirvtlmmdatnmpavkaiiyq
    ymeeiyhripdsdpsssktrqiistirtq
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >3wefE (E:)
    gshmdqdslssslktcykylnqtsrsfaaviqaldgemrnavcifylvlraldtleddmt
    isvekkvpllhnfhsflyqpdwrfmeskekdrqvledfptislefrnlaekyqtviadic
    rrmgigmaefldkhvtseqewdkychyvaglvgiglsrlfsasefedplvgedteransm
    glflqktniirdyledqqggrefwpqevwsryvkklgdfakpenidlavqclnelitnal
    hhipdvitylsrlrnqsvfnfcaipqvmaiatlaacynnqqvfkgavkirkgqavtlmmd
    atnmpavkaiiyqymeeiyhripdsdpsssktrqiistirtqn
    

    Sequence, based on observed residues (ATOM records): (download)
    >3wefE (E:)
    ssslktcykylnqtsrsfaaviqaldgemrnavcifylvlraldtleddmtisvekkvpl
    lhnfhsflyqpdwrfmeskekdrqvledfptislefrnlaekyqtviadicrrmgigmae
    fldkhvtseqewdkychyvaglvgiglsrlfsasefedplvgedteransmglflqktni
    irdyledqqggrefwpqevwsryvkklgdfakpenidlavqclnelitnalhhipdvity
    lsrlrnqsvfnfcaipqvmaiatlaacynnqqvfkgavkiavtlmmdatnmpavkaiiyq
    ymeeiyhripdsdpsssktrqiistirtq
    

  • Chain 'F':
    Sequence, based on SEQRES records: (download)
    >3wefF (F:)
    gshmdqdslssslktcykylnqtsrsfaaviqaldgemrnavcifylvlraldtleddmt
    isvekkvpllhnfhsflyqpdwrfmeskekdrqvledfptislefrnlaekyqtviadic
    rrmgigmaefldkhvtseqewdkychyvaglvgiglsrlfsasefedplvgedteransm
    glflqktniirdyledqqggrefwpqevwsryvkklgdfakpenidlavqclnelitnal
    hhipdvitylsrlrnqsvfnfcaipqvmaiatlaacynnqqvfkgavkirkgqavtlmmd
    atnmpavkaiiyqymeeiyhripdsdpsssktrqiistirtqn
    

    Sequence, based on observed residues (ATOM records): (download)
    >3wefF (F:)
    sslktcykylnqtsrsfaaviqaldgemrnavcifylvlraldtleddmtisvekkvpll
    hnfhsflyqpdwrfmeskekdrqvledfptislefrnlaekyqtviadicrrmgigmaef
    ldkhvtseqewdkychyvaglvgiglsrlfsasefedplvgedteransmglflqktnii
    rdyledqqggrefwpqevwsryvkklgdfakpenidlavqclnelitnalhhipdvityl
    srlrnqsvfnfcaipqvmaiatlaacynnqqvfkgavmmdatnmpavkaiiyqymeeiyh
    ripdsdpsssktrqiistirtq