PDB entry 3w2o
View 3w2o on RCSB PDB site
Description: EGFR Kinase domain T790M/L858R Mutant with TAK-285
Class: transferase/transferase inhibitor
Keywords: ANTI-ONCOGENE, CELL CYCLE, DISEASE MUTATION, KINASE DOMAIN, RECEPTOR, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on
2012-12-03, released
2013-01-16
The last revision prior to the SCOPe 2.05 freeze date was dated
2013-08-21, with a file datestamp of
2013-08-16.
Experiment type: XRAY
Resolution: 2.35 Å
R-factor: 0.182
AEROSPACI score: 0.39
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Epidermal growth factor receptor
Species: Homo sapiens [TaxId:9606]
Gene: EGFR, ERBB, ERBB1, HER1
Database cross-references and differences (RAF-indexed):
- Uniprot P00533 (6-End)
- expression tag (5)
- engineered mutation (98)
- engineered mutation (166)
Domains in SCOPe 2.05: d3w2oa_ - Heterogens: 03P, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3w2oA (A:)
hhhhhhapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreat
spkankeildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigs
qyllnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfgrakllgaeekeyha
eggkvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekge
rlpqppictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlps
ptdsnfyralmdeedmddvvdadeylipqqg
Sequence, based on observed residues (ATOM records): (download)
>3w2oA (A:)
hapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkan
keildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqylln
wcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfgrakllgaeekeyhaeggkv
pikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqp
pictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpmddvvd
adeyl