PDB entry 3w0t

View 3w0t on RCSB PDB site
Description: Human Glyoxalase I with an N-hydroxypyridone derivative inhibitor
Class: lyase/lyase inhibitor
Keywords: Glyoxalase, LYASE-LYASE INHIBITOR complex
Deposited on 2012-11-02, released 2013-11-06
The last revision prior to the SCOPe 2.08 freeze date was dated 2013-11-06, with a file datestamp of 2013-11-01.
Experiment type: XRAY
Resolution: 1.35 Å
R-factor: 0.176
AEROSPACI score: 0.63 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: lactoylglutathione lyase
    Species: Homo sapiens [TaxId:9606]
    Gene: Glo1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3w0ta_
  • Chain 'B':
    Compound: lactoylglutathione lyase
    Species: Homo sapiens [TaxId:9606]
    Gene: Glo1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3w0tb_
  • Chain 'C':
    Compound: lactoylglutathione lyase
    Species: Homo sapiens [TaxId:9606]
    Gene: Glo1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3w0tc_
  • Chain 'D':
    Compound: lactoylglutathione lyase
    Species: Homo sapiens [TaxId:9606]
    Gene: Glo1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3w0td_
  • Heterogens: ZN, HPU, EPE, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3w0tA (A:)
    gshmaepqppsggltdeaalsccsdadpstkdfllqqtmlrvkdpkksldfytrvlgmtl
    iqkcdfpimkfslyflayedkndipkekdekiawalsrkatlelthnwgteddetqsyhn
    gnsdprgfghigiavpdvysackrfeelgvkfvkkpddgkmkglafiqdpdgywieilnp
    nkmatlm
    

    Sequence, based on observed residues (ATOM records): (download)
    >3w0tA (A:)
    ggltdeaalsccsdadpstkdfllqqtmlrvkdpkksldfytrvlgmtliqkcdfpimkf
    slyflayedkndipkekdekiawalsrkatlelthnwgteddetqsyhngnsdprgfghi
    giavpdvysackrfeelgvkfvkkpddgkmkglafiqdpdgywieilnpnkmatlm
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >3w0tB (B:)
    gshmaepqppsggltdeaalsccsdadpstkdfllqqtmlrvkdpkksldfytrvlgmtl
    iqkcdfpimkfslyflayedkndipkekdekiawalsrkatlelthnwgteddetqsyhn
    gnsdprgfghigiavpdvysackrfeelgvkfvkkpddgkmkglafiqdpdgywieilnp
    nkmatlm
    

    Sequence, based on observed residues (ATOM records): (download)
    >3w0tB (B:)
    epqppsggltdeaalsccsdadpstkdfllqqtmlrvkdpkksldfytrvlgmtliqkcd
    fpimkfslyflayedkndipkekdekiawalsrkatlelthnwgteddetqsyhngnsdp
    rgfghigiavpdvysackrfeelgvkfvkkpddgkmkglafiqdpdgywieilnpnkmat
    lm
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >3w0tC (C:)
    gshmaepqppsggltdeaalsccsdadpstkdfllqqtmlrvkdpkksldfytrvlgmtl
    iqkcdfpimkfslyflayedkndipkekdekiawalsrkatlelthnwgteddetqsyhn
    gnsdprgfghigiavpdvysackrfeelgvkfvkkpddgkmkglafiqdpdgywieilnp
    nkmatlm
    

    Sequence, based on observed residues (ATOM records): (download)
    >3w0tC (C:)
    ggltdeaalsccsdadpstkdfllqqtmlrvkdpkksldfytrvlgmtliqkcdfpimkf
    slyflayedkndipkekdekiawalsrkatlelthnwgteddetqsyhngnsdprgfghi
    giavpdvysackrfeelgvkfvkkpddgkmkglafiqdpdgywieilnpnkmatlm
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >3w0tD (D:)
    gshmaepqppsggltdeaalsccsdadpstkdfllqqtmlrvkdpkksldfytrvlgmtl
    iqkcdfpimkfslyflayedkndipkekdekiawalsrkatlelthnwgteddetqsyhn
    gnsdprgfghigiavpdvysackrfeelgvkfvkkpddgkmkglafiqdpdgywieilnp
    nkmatlm
    

    Sequence, based on observed residues (ATOM records): (download)
    >3w0tD (D:)
    ggltdeaalsccsdadpstkdfllqqtmlrvkdpkksldfytrvlgmtliqkcdfpimkf
    slyflayedkndipkekdekiawalsrkatlelthnwgteddetqsyhngnsdprgfghi
    giavpdvysackrfeelgvkfvkkpddgkmkglafiqdpdgywieilnpnkmatlm