PDB entry 3vw6

View 3vw6 on RCSB PDB site
Description: Crystal structure of human apoptosis signal-regulating kinase 1 (ASK1) with imidazopyridine inhibitor
Class: transferase/transferase inhibitor
Keywords: Transferase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2012-08-06, released 2012-10-31
The last revision prior to the SCOPe 2.03 freeze date was dated 2012-10-31, with a file datestamp of 2012-10-26.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.215
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: mitogen-activated protein kinase kinase kinase 5
    Species: Homo sapiens [TaxId:9606]
    Gene: MAP3K5, ASK1, MAPKKK5, MEKK5
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d3vw6a_
  • Chain 'B':
    Compound: mitogen-activated protein kinase kinase kinase 5
    Species: Homo sapiens [TaxId:9606]
    Gene: MAP3K5, ASK1, MAPKKK5, MEKK5
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d3vw6b_
  • Heterogens: IM6, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3vw6A (A:)
leydyeydengdrvvlgkgtygivyagrdlsnqvriaikeiperdsrysqplheeialhk
hlkhknivqylgsfsengfikifmeqvpggslsallrskwgplkdneqtigfytkqileg
lkylhdnqivhrdikgdnvlintysgvlkisdfgtskrlaginpctetftgtlqymapei
idkgprgygkaadiwslgctiiematgkppfyelgepqaamfkvgmfkvhpeipesmsae
akafilkcfepdpdkracandllvdeflk

    Sequence, based on observed residues (ATOM records): (download) 
    >3vw6A (A:)
leydyeydengdrvvlgkgtygivyagrdlsnqvriaikeipeqplheeialhkhlkhkn
ivqylgsfsengfikifmeqvpggslsallrskwgplkdneqtigfytkqileglkylhd
nqivhrdikgdnvlintysgvlkisdfgtskrltftgtlqymapeiidkgprgygkaadi
wslgctiiematgkppfyelgepqaamfkvgmfkvhpeipesmsaeakafilkcfepdpd
kracandllvdeflk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3vw6B (B:)
leydyeydengdrvvlgkgtygivyagrdlsnqvriaikeiperdsrysqplheeialhk
hlkhknivqylgsfsengfikifmeqvpggslsallrskwgplkdneqtigfytkqileg
lkylhdnqivhrdikgdnvlintysgvlkisdfgtskrlaginpctetftgtlqymapei
idkgprgygkaadiwslgctiiematgkppfyelgepqaamfkvgmfkvhpeipesmsae
akafilkcfepdpdkracandllvdeflk

    Sequence, based on observed residues (ATOM records): (download) 
    >3vw6B (B:)
leydyeydengdrvvlgkgtygivyagrdlsnqvriaikeipeqplheeialhkhlkhkn
ivqylgsfsengfikifmeqvpggslsallrskwgplkdneqtigfytkqileglkylhd
nqivhrdikgdnvlintysgvlkisdfgtskrltgtlqymapeiidkgprgygkaadiws
lgctiiematgkppfyelgepqaamfkvgmfkvhpeipesmsaeakafilkcfepdpdkr
acandllvdeflk