PDB entry 3vrq
View 3vrq on RCSB PDB site
Description: Crystal structure of the tyrosine kinase binding domain of Cbl-c (PL mutant)
Class: protein binding
Keywords: PTB domain, TKB (tyrosine kinase binding) domain, four-helix bundle (4H), calcium-binding EF hand, divergent SH2 domain, Regulator of EGFR mediated signal transduction, Ubiquitously expressed, PROTEIN BINDING
Deposited on
2012-04-13, released
2013-03-06
The last revision prior to the SCOPe 2.07 freeze date was dated
2013-03-06, with a file datestamp of
2013-03-01.
Experiment type: XRAY
Resolution: 2.39 Å
R-factor: 0.218
AEROSPACI score: 0.33
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Signal transduction protein CBL-C
Species: Homo sapiens [TaxId:9606]
Gene: CBLC
Database cross-references and differences (RAF-indexed):
- Uniprot Q9ULV8
- engineered mutation (272)
Domains in SCOPe 2.07: d3vrqa1, d3vrqa2, d3vrqa3 - Chain 'B':
Compound: Signal transduction protein CBL-C
Species: Homo sapiens [TaxId:9606]
Gene: CBLC
Database cross-references and differences (RAF-indexed):
- Uniprot Q9ULV8
- engineered mutation (272)
Domains in SCOPe 2.07: d3vrqb1, d3vrqb2, d3vrqb3 - Heterogens: CA, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3vrqA (A:)
gplgspefmalavapwgrqweearalgravrmlqrleeqcvdprlsvsppslrdllprta
qllrevahsrraaggggpggpggsgdflliylanleaksrqvaallpprgrrsandelfr
agsrlrrqlaklaiifshmhaelhalfpggkycghmyqltkapahtfwrescgarcvlpw
aefesllgtchpvepgctalalrttidltcsghvsifefdvftrlfqpwptllknwqlla
vnhpgymafltydevqerlqacrdkpgsyifrlsctrlgqwaigyvssdgsilqtipank
plsqvllegqkdgfylypdgkthnpdltelg
Sequence, based on observed residues (ATOM records): (download)
>3vrqA (A:)
qweearalgravrmlqrleeqcppslrdllprtaqllrevahsrpggpggsgdflliyla
nleaksrqvaalsrlrrqlaklaiifshmhaelhalfpggkycghmyqltkapahtfwre
scgarcvlpwaefesllgtchpvepgctalalrttidltcsghvsifefdvftrlfqpwp
tllknwqllavnhpgymafltydevqerlqacrdkpgsyifrlsctrlgqwaigyvssdg
silqtipankplsqvllegqkdgfylypdgkthnpdlt
- Chain 'B':
Sequence, based on SEQRES records: (download)
>3vrqB (B:)
gplgspefmalavapwgrqweearalgravrmlqrleeqcvdprlsvsppslrdllprta
qllrevahsrraaggggpggpggsgdflliylanleaksrqvaallpprgrrsandelfr
agsrlrrqlaklaiifshmhaelhalfpggkycghmyqltkapahtfwrescgarcvlpw
aefesllgtchpvepgctalalrttidltcsghvsifefdvftrlfqpwptllknwqlla
vnhpgymafltydevqerlqacrdkpgsyifrlsctrlgqwaigyvssdgsilqtipank
plsqvllegqkdgfylypdgkthnpdltelg
Sequence, based on observed residues (ATOM records): (download)
>3vrqB (B:)
weearalgravrmlqrleeqcvsppslrdllprtaqllrevahsrrapggpggsgdflli
ylanleaksrqvaalrlrrqlaklaiifshmhaelhalfpggkycghmyqltkapahtfw
rescgarcvlpwaefesllgtchptalalrttidltcsghvsifefdvftrlfqpwptll
knwqllavnhpgymafltydevqerlqacrdkpgsyifrlsctrlgqwaigyvssdgsil
qtipankplsqvllegqkdgfylypdgkthnpdlt