PDB entry 3vjo

View 3vjo on RCSB PDB site
Description: Crystal structure of the wild-type EGFR kinase domain in complex with AMPPNP.
Class: transferase
Keywords: receptor, disease mutation, cell cycle, drug resistance, kinase, tyrosine-protein kinase, transferase, ATP binding, phosphorylation, transmembrane
Deposited on 2011-10-27, released 2012-03-07
The last revision prior to the SCOPe 2.05 freeze date was dated 2013-06-26, with a file datestamp of 2013-06-21.
Experiment type: XRAY
Resolution: 2.64 Å
R-factor: 0.19
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d3vjoa_
  • Heterogens: ANP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3vjoA (A:)
gamgirsgeapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelr
eatspkankeildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdn
igsqyllnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeeke
yhaeggkvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissile
kgerlpqppictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermh
lpsptdsnfyralmdeedmddvvdadeylipqqg

    Sequence, based on observed residues (ATOM records): (download) 
    >3vjoA (A:)
geapnqallrilketefkkikvlgsfgtvykglwipegekvkipvaikeatspkankeil
deayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyllnwcvq
iakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggkvpikw
malesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppict
idvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdedmddvvdadeyli