PDB entry 3vjk

View 3vjk on RCSB PDB site
Description: Crystal structure of human depiptidyl peptidase IV (DPP-4) in complex with MP-513
Class: hydrolase/hydrolase inhibitor
Keywords: ALPHA/BETA, BETA-PROPELLER, AMINOPEPTIDASE, SERINE PROTEASE, SIGNAL-ANCHOR, TRANSMEMBRANE, DIABETES, GLYCOPROTEIN, CELL MEMBRANE, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2011-10-24, released 2012-10-24
The last revision prior to the SCOPe 2.05 freeze date was dated 2012-10-24, with a file datestamp of 2012-10-19.
Experiment type: XRAY
Resolution: 2.49 Å
R-factor: 0.228
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dipeptidyl peptidase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: DPP4, ADCP2, CD26
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d3vjka1, d3vjka2
  • Chain 'B':
    Compound: dipeptidyl peptidase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: DPP4, ADCP2, CD26
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d3vjkb1, d3vjkb2
  • Heterogens: M51, NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3vjkA (A:)
ddatadsrktytltdylkntyrlklyslrwisdheylykqennilvfnaeygnssvflen
stfdefghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnnt
qwvtwspvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsays
alwwspngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvn
tdslssvtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdyde
ssgrwnclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkk
dctfitkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpe
rcqyysvsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpsk
kldfiilnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasten
iivasfdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyg
gyvtsmvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsra
enfkqveyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiy
thmshfikqcfslphhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3vjkA (A:)
dsrktytltdylkntyrlklyslrwisdheylykqennilvfnaeygnssvflenstfde
fghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnntqwvtw
spvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsaysalwws
pngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvntdsls
svtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdydessgrw
nclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkkdctfi
tkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpercqyy
svsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpskkldfi
ilnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasteniivas
fdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyggyvts
mvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsraenfkq
veyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiythmsh
fikqcfslp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3vjkB (B:)
ddatadsrktytltdylkntyrlklyslrwisdheylykqennilvfnaeygnssvflen
stfdefghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnnt
qwvtwspvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsays
alwwspngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvn
tdslssvtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdyde
ssgrwnclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkk
dctfitkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpe
rcqyysvsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpsk
kldfiilnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasten
iivasfdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyg
gyvtsmvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsra
enfkqveyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiy
thmshfikqcfslphhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3vjkB (B:)
dsrktytltdylkntyrlklyslrwisdheylykqennilvfnaeygnssvflenstfde
fghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnntqwvtw
spvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsaysalwws
pngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvntdsls
svtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdydessgrw
nclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkkdctfi
tkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpercqyy
svsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpskkldfi
ilnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasteniivas
fdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyggyvts
mvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsraenfkq
veyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiythmsh
fikqcfslp