PDB entry 3vjc

View 3vjc on RCSB PDB site
Description: Crystal structure of the human squalene synthase in complex with zaragozic acid A
Class: Transferase/Transferase inhibitor
Keywords: Farnesyl-diphosphate farnesyltransferase, Head-to-head synthases, Cholesterol biosynthesis, Oxidoreductase, Transferase-Transferase inhibitor complex
Deposited on 2011-10-14, released 2012-04-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2013-07-24, with a file datestamp of 2013-07-19.
Experiment type: XRAY
Resolution: 1.89 Å
R-factor: 0.15
AEROSPACI score: 0.53 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Squalene synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: FDFT1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3vjca_
  • Chain 'B':
    Compound: Squalene synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: FDFT1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3vjcb_
  • Chain 'C':
    Compound: Squalene synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: FDFT1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3vjcc_
  • Chain 'D':
    Compound: Squalene synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: FDFT1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3vjcd_
  • Chain 'E':
    Compound: Squalene synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: FDFT1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3vjce_
  • Chain 'F':
    Compound: Squalene synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: FDFT1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3vjcf_
  • Heterogens: ZGA, PO4, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3vjcA (A:)
gshmdqdslssslktcykylnqtsrsfaaviqaldgemrnavcifylvlraldtleddmt
isvekkvpllhnfhsflyqpdwrfmeskekdrqvledfptislefrnlaekyqtviadic
rrmgigmaefldkhvtseqewdkychyvaglvgiglsrlfsasefedplvgedteransm
glflqktniirdyledqqggrefwpqevwsryvkklgdfakpenidlavqclnelitnal
hhipdvitylsrlrnqsvfnfcaipqvmaiatlaacynnqqvfkgavkirkgqavtlmmd
atnmpavkaiiyqymeeiyhripdsdpsssktrqiistirtqn

    Sequence, based on observed residues (ATOM records): (download) 
    >3vjcA (A:)
lssslktcykylnqtsrsfaaviqaldgemrnavcifylvlraldtleddmtisvekkvp
llhnfhsflyqpdwrfmeskekdrqvledfptislefrnlaekyqtviadicrrmgigma
efldkhvtseqewdkychyvaglvgiglsrlfsasefedplvgedteransmglflqktn
iirdyledqqggrefwpqevwsryvkklgdfakpenidlavqclnelitnalhhipdvit
ylsrlrnqsvfnfcaipqvmaiatlaacynnqqvfkgavkirkgqavtlmmdatnmpavk
aiiyqymeeiyhripdsdpsssktrqiistirtq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3vjcB (B:)
gshmdqdslssslktcykylnqtsrsfaaviqaldgemrnavcifylvlraldtleddmt
isvekkvpllhnfhsflyqpdwrfmeskekdrqvledfptislefrnlaekyqtviadic
rrmgigmaefldkhvtseqewdkychyvaglvgiglsrlfsasefedplvgedteransm
glflqktniirdyledqqggrefwpqevwsryvkklgdfakpenidlavqclnelitnal
hhipdvitylsrlrnqsvfnfcaipqvmaiatlaacynnqqvfkgavkirkgqavtlmmd
atnmpavkaiiyqymeeiyhripdsdpsssktrqiistirtqn

    Sequence, based on observed residues (ATOM records): (download) 
    >3vjcB (B:)
ssslktcykylnqtsrsfaaviqaldgemrnavcifylvlraldtleddmtisvekkvpl
lhnfhsflyqpdwrfmeskekdrqvledfptislefrnlaekyqtviadicrrmgigmae
fldkhvtseqewdkychyvaglvgiglsrlfsasefedplvgedteransmglflqktni
irdyledqqggrefwpqevwsryvkklgdfakpenidlavqclnelitnalhhipdvity
lsrlrnqsvfnfcaipqvmaiatlaacynnqqvfkgavkirkgqavtlmmdatnmpavka
iiyqymeeiyhripdsdpsssktrqiistirtq

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3vjcC (C:)
gshmdqdslssslktcykylnqtsrsfaaviqaldgemrnavcifylvlraldtleddmt
isvekkvpllhnfhsflyqpdwrfmeskekdrqvledfptislefrnlaekyqtviadic
rrmgigmaefldkhvtseqewdkychyvaglvgiglsrlfsasefedplvgedteransm
glflqktniirdyledqqggrefwpqevwsryvkklgdfakpenidlavqclnelitnal
hhipdvitylsrlrnqsvfnfcaipqvmaiatlaacynnqqvfkgavkirkgqavtlmmd
atnmpavkaiiyqymeeiyhripdsdpsssktrqiistirtqn

    Sequence, based on observed residues (ATOM records): (download) 
    >3vjcC (C:)
ssslktcykylnqtsrsfaaviqaldgemrnavcifylvlraldtleddmtisvekkvpl
lhnfhsflyqpdwrfmeskekdrqvledfptislefrnlaekyqtviadicrrmgigmae
fldkhvtseqewdkychyvaglvgiglsrlfsasefedplvgedteransmglflqktni
irdyledqqggrefwpqevwsryvkklgdfakpenidlavqclnelitnalhhipdvity
lsrlrnqsvfnfcaipqvmaiatlaacynnqqvfkgavkirkgqavtlmmdatnmpavka
iiyqymeeiyhripdsdpsssktrqiistirt

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3vjcD (D:)
gshmdqdslssslktcykylnqtsrsfaaviqaldgemrnavcifylvlraldtleddmt
isvekkvpllhnfhsflyqpdwrfmeskekdrqvledfptislefrnlaekyqtviadic
rrmgigmaefldkhvtseqewdkychyvaglvgiglsrlfsasefedplvgedteransm
glflqktniirdyledqqggrefwpqevwsryvkklgdfakpenidlavqclnelitnal
hhipdvitylsrlrnqsvfnfcaipqvmaiatlaacynnqqvfkgavkirkgqavtlmmd
atnmpavkaiiyqymeeiyhripdsdpsssktrqiistirtqn

    Sequence, based on observed residues (ATOM records): (download) 
    >3vjcD (D:)
ssslktcykylnqtsrsfaaviqaldgemrnavcifylvlraldtleddmtisvekkvpl
lhnfhsflyqpdwrfmeskekdrqvledfptislefrnlaekyqtviadicrrmgigmae
fldkhvtseqewdkychyvaglvgiglsrlfsasefedplvgedteransmglflqktni
irdyledqqggrefwpqevwsryvkklgdfakpenidlavqclnelitnalhhipdvity
lsrlrnqsvfnfcaipqvmaiatlaacynnqqvfkgavkirkgqavtlmmdatnmpavka
iiyqymeeiyhripdsdpsssktrqiistirtq

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >3vjcE (E:)
gshmdqdslssslktcykylnqtsrsfaaviqaldgemrnavcifylvlraldtleddmt
isvekkvpllhnfhsflyqpdwrfmeskekdrqvledfptislefrnlaekyqtviadic
rrmgigmaefldkhvtseqewdkychyvaglvgiglsrlfsasefedplvgedteransm
glflqktniirdyledqqggrefwpqevwsryvkklgdfakpenidlavqclnelitnal
hhipdvitylsrlrnqsvfnfcaipqvmaiatlaacynnqqvfkgavkirkgqavtlmmd
atnmpavkaiiyqymeeiyhripdsdpsssktrqiistirtqn

    Sequence, based on observed residues (ATOM records): (download) 
    >3vjcE (E:)
ssslktcykylnqtsrsfaaviqaldgemrnavcifylvlraldtleddmtisvekkvpl
lhnfhsflyqpdwrfmeskekdrqvledfptislefrnlaekyqtviadicrrmgigmae
fldkhvtseqewdkychyvaglvgiglsrlfsasefedplvgedteransmglflqktni
irdyledqqggrefwpqevwsryvkklgdfakpenidlavqclnelitnalhhipdvity
lsrlrnqsvfnfcaipqvmaiatlaacynnqqvfkgavkirkgqavtlmmdatnmpavka
iiyqymeeiyhripdsdpsssktrqiistirtq

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >3vjcF (F:)
gshmdqdslssslktcykylnqtsrsfaaviqaldgemrnavcifylvlraldtleddmt
isvekkvpllhnfhsflyqpdwrfmeskekdrqvledfptislefrnlaekyqtviadic
rrmgigmaefldkhvtseqewdkychyvaglvgiglsrlfsasefedplvgedteransm
glflqktniirdyledqqggrefwpqevwsryvkklgdfakpenidlavqclnelitnal
hhipdvitylsrlrnqsvfnfcaipqvmaiatlaacynnqqvfkgavkirkgqavtlmmd
atnmpavkaiiyqymeeiyhripdsdpsssktrqiistirtqn

    Sequence, based on observed residues (ATOM records): (download) 
    >3vjcF (F:)
sslktcykylnqtsrsfaaviqaldgemrnavcifylvlraldtleddmtisvekkvpll
hnfhsflyqpdwrfmeskekdrqvledfptislefrnlaekyqtviadicrrmgigmaef
ldkhvtseqewdkychyvaglvgiglsrlfsasefedplvgedteransmglflqktnii
rdyledqqggrefwpqevwsryvkklgdfakpenidlavqclnelitnalhhipdvityl
srlrnqsvfnfcaipqvmaiatlaacynnqqvfkgavkirkgqavtlmmdatnmpavkai
iyqymeeiyhripdsdpsssktrqiistirtq