PDB entry 3va2

View 3va2 on RCSB PDB site
Description: Crystal structure of human Interleukin-5 in complex with its alpha receptor
Class: cytokine/cytokine receptor
Keywords: cytokine, eosinophilic, asthma, JAK/STAT, fibronectin III-like (Fn III) domain, canonical cytokine receptor homology module (CRM), B cell growth, Ig secretion, eosinophils proliferation, cell surface, CYTOKINE-CYTOKINE RECEPTOR complex
Deposited on 2011-12-28, released 2012-07-25
The last revision prior to the SCOPe 2.06 freeze date was dated 2012-07-25, with a file datestamp of 2012-07-20.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: 0.225
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Interleukin-5
    Species: Homo sapiens [TaxId:9606]
    Gene: Il5
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3va2a_
  • Chain 'B':
    Compound: Interleukin-5
    Species: Homo sapiens [TaxId:9606]
    Gene: Il5
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3va2b_
  • Chain 'C':
    Compound: Interleukin-5 receptor subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: IL5RA, IL5R
    Database cross-references and differences (RAF-indexed):
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3va2A (A:)
    gssgssgeiptsalvketlallsthrtllianetlripvpvhknhqlcteeifqgigtle
    sqtvqggtverlfknlslikkyidgqkkkcgeerrrvnqfldylqeflgvmntewiies
    

    Sequence, based on observed residues (ATOM records): (download)
    >3va2A (A:)
    iptsalvketlallsthrtllianetlripvpvhknhqlcteeifqgigtlesqtvqggt
    verlfknlslikkyidgqkkkcgeerrrvnqfldylqeflgvmntew
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >3va2B (B:)
    gssgssgeiptsalvketlallsthrtllianetlripvpvhknhqlcteeifqgigtle
    sqtvqggtverlfknlslikkyidgqkkkcgeerrrvnqfldylqeflgvmntewiies
    

    Sequence, based on observed residues (ATOM records): (download)
    >3va2B (B:)
    iptsalvketlallsthrtllianetlripvpvhknhqlcteeifqgigtlesqtvqggt
    verlfknlslikkyidgqkkkcgeerrrvnqfldylqeflgvmntewii
    

  • Chain 'C':
    No sequence available.