PDB entry 3v5w

View 3v5w on RCSB PDB site
Description: Human G Protein-Coupled Receptor Kinase 2 in Complex with Soluble Gbetagamma Subunits and Paroxetine
Class: transferase/transferase inhibitor
Keywords: Inhibitor complex, Protein kinase, Beta propeller, RGS homology domain, Pleckstrin homology domain, Kinase, Signal transduction, Peripheral membrane protein, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2011-12-17, released 2012-09-26
The last revision prior to the SCOPe 2.02 freeze date was dated 2012-12-12, with a file datestamp of 2012-12-07.
Experiment type: XRAY
Resolution: 2.07 Å
R-factor: 0.196
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: g-protein coupled receptor kinase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: ADRBK1, BARK, BARK1, GRK2
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Species: Bos taurus [TaxId:9913]
    Gene: GNB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d3v5wb_
  • Chain 'G':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Species: Bos taurus [TaxId:9913]
    Gene: GNG2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d3v5wg_
  • Heterogens: 8PR, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3v5wB (B:)
mseldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiya
mhwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldni
csiynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttf
tghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngna
fatgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdal
kadragvlaghdnrvsclgvtddgmavatgswdsflkiwn

    Sequence, based on observed residues (ATOM records): (download) 
    >3v5wB (B:)
seldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiyam
hwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldnic
siynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttft
ghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngnaf
atgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdalk
adragvlaghdnrvsclgvtddgmavatgswdsflkiwn

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >3v5wG (G:)
hhhhhhmasnntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpv
pasenpfrekkffsail

    Sequence, based on observed residues (ATOM records): (download) 
    >3v5wG (G:)
siaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpfrek