PDB entry 3v4k
View 3v4k on RCSB PDB site
Description: First-In-Class Small Molecule Inhibitors of the Single-strand DNA Cytosine Deaminase APOBEC3G
Class: hydrolase
Keywords: APOBEC3G, ANTIVIRAL DEFENSE, HOST-VIRUS INTERACTION, HYDROLASE, METAL-BINDING, Nucleus
Deposited on
2011-12-15, released
2012-01-25
The last revision prior to the SCOPe 2.08 freeze date was dated
2017-11-08, with a file datestamp of
2017-11-03.
Experiment type: XRAY
Resolution: 1.38 Å
R-factor: N/A
AEROSPACI score: 0.54
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: DNA dC->dU-editing enzyme APOBEC-3G
Species: Homo sapiens [TaxId:9606]
Gene: APOBEC3G, MDS019
Database cross-references and differences (RAF-indexed):
- Uniprot Q9HC16 (Start-202)
- engineered mutation (56)
- engineered mutation (65)
- engineered mutation (132)
- engineered mutation (178)
Domains in SCOPe 2.08: d3v4ka_ - Chain 'B':
Compound: DNA dC->dU-editing enzyme APOBEC-3G
Species: Homo sapiens [TaxId:9606]
Gene: APOBEC3G, MDS019
Database cross-references and differences (RAF-indexed):
- Uniprot Q9HC16 (Start-202)
- engineered mutation (56)
- engineered mutation (65)
- engineered mutation (132)
- engineered mutation (178)
Domains in SCOPe 2.08: d3v4kb_ - Heterogens: CL, MG, ZN, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3v4kA (A:)
gplgspefelgtteilrhsmdpptftfnfnnepwvrgrhetylcyevermhndtwvklnq
rrgflanqaphkhgflegrhaelcfldvipfwkldldqdyrvtcftswspcfscaqemak
fisknkhvslciktariyddqgrcqeglrtlaeagakisimtysefkhcwdtfvdhqgap
fqpwdgldehsqdlsgrlrailq
Sequence, based on observed residues (ATOM records): (download)
>3v4kA (A:)
hsmdpptftfnfnnepwvrgrhetylcyevermhndtwvklnqrrgflanqaphkhgfle
grhaelcfldvipfwkldldqdyrvtcftswspcfscaqemakfisknkhvslciktari
yddqgrcqeglrtlaeagakisimtysefkhcwdtfvdhqgapfqpwdgldehsqdlsgr
lrailq
- Chain 'B':
Sequence, based on SEQRES records: (download)
>3v4kB (B:)
gplgspefelgtteilrhsmdpptftfnfnnepwvrgrhetylcyevermhndtwvklnq
rrgflanqaphkhgflegrhaelcfldvipfwkldldqdyrvtcftswspcfscaqemak
fisknkhvslciktariyddqgrcqeglrtlaeagakisimtysefkhcwdtfvdhqgap
fqpwdgldehsqdlsgrlrailq
Sequence, based on observed residues (ATOM records): (download)
>3v4kB (B:)
hsmdpptftfnfnnepwvrgrhetylcyevermhndtwvklnqrrgflanqaphkhgfle
grhaelcfldvipfwkldldqdyrvtcftswspcfscaqemakfisknkhvslciktari
yddqgrcqeglrtlaeagakisimtysefkhcwdtfvdhqgapfqpwdgldehsqdlsgr
lrailq