PDB entry 3uvy

View 3uvy on RCSB PDB site
Description: Crystal Structure of the first bromodomain of human BRD4 in complex with a diacetylated histone 4 peptide (H4K16acK20ac)
Class: transcription/protein binding
Keywords: Bromodomain, Bromodomain containing protein 4, CAP, HUNK1, MCAP, Mitotic chromosome associated protein, peptide complex, Structural Genomics Consortium, SGC, TRANSCRIPTION, TRANSCRIPTION-PROTEIN BINDING complex
Deposited on 2011-11-30, released 2012-01-18
The last revision prior to the SCOPe 2.04 freeze date was dated 2012-08-29, with a file datestamp of 2012-08-24.
Experiment type: XRAY
Resolution: 2.02 Å
R-factor: 0.186
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Bromodomain-containing protein 4
  Species: Homo sapiens [TaxId:9606]
  Gene: BRD4, HUNK1
  Database cross-references and differences (RAF-indexed):
  • Uniprot O60885
  Domains in SCOPe 2.04: d3uvya_
• Chain 'B':
  Compound: histone h4
  Species: HOMO SAPIENS, synthetic [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P62805 (0-End)
• Heterogens: HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence, based on SEQRES records: (download)
  

  >3uvyA (A:)
  smnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykii
  ktpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqki
  nelptee
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >3uvyA (A:)
  qtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykiiktpmdmgtikkrlenny
  ywnaqeciqdfntmftncyiynkpgddivlmaealeklflqkinelpte
  

  
  
• Chain 'B':
  No sequence available.