PDB entry 3uvw

View 3uvw on RCSB PDB site
Description: Crystal Structure of the first bromodomain of human BRD4 in complex with a diacetylated histone 4 peptide (H4K5acK8ac)
Class: transcription/protein binding
Keywords: Bromodomain, Bromodomain containing protein 4, CAP, HUNK1, MCAP, Mitotic chromosome associated protein, peptide complex, Structural Genomics Consortium, SGC, PROTEIN BINDING, TRANSCRIPTION, TRANSCRIPTION-PROTEIN BINDING complex
Deposited on 2011-11-30, released 2012-01-18
The last revision prior to the SCOPe 2.05 freeze date was dated 2012-08-29, with a file datestamp of 2012-08-24.
Experiment type: XRAY
Resolution: 1.37 Å
R-factor: 0.127
AEROSPACI score: 0.76 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bromodomain-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD4, HUNK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60885 (2-126)
      • expression tag (0-1)
    Domains in SCOPe 2.05: d3uvwa_
  • Chain 'B':
    Compound: histone h4
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P62805 (0-10)
      • expression tag (11)
  • Heterogens: EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3uvwA (A:)
smnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykii
ktpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqki
nelptee

  • Chain 'B':
    No sequence available.