PDB entry 3uvl

View 3uvl on RCSB PDB site
Description: Crystal structure of WDR5 in complex with the WDR5-interacting motif of MLL3
Class: transcription
Keywords: trithorax, chromatin biology, beta-propeller, scaffolding, histone H3, nucleus, TRANSCRIPTION
Deposited on 2011-11-30, released 2011-12-14
The last revision prior to the SCOPe 2.07 freeze date was dated 2012-05-30, with a file datestamp of 2012-05-25.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.172
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: WD repeat-containing protein 5
    Species: Homo sapiens [TaxId:9606]
    Gene: WDR5, BIG3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3uvla_
  • Chain 'B':
    Compound: Histone-lysine N-methyltransferase MLL3
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8NEZ4 (0-End)
      • engineered mutation (1)
      • engineered mutation (4)
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3uvlA (A:)
gamgssatqskptpvkpnyalkftlaghtkavssvkfspngewlasssadklikiwgayd
gkfektisghklgisdvawssdsnllvsasddktlkiwdvssgkclktlkghsnyvfccn
fnpqsnlivsgsfdesvriwdvktgkclktlpahsdpvsavhfnrdgslivsssydglcr
iwdtasgqclktlidddnppvsfvkfspngkyilaatldntlklwdyskgkclktytghk
nekycifanfsvtggkwivsgsednlvyiwnlqtkeivqklqghtdvvistachptenii
asaalendktiklwksdc

    Sequence, based on observed residues (ATOM records): (download) 
    >3uvlA (A:)
vkpnyalkftlaghtkavssvkfspngewlasssadklikiwgaydgkfektisghklgi
sdvawssdsnllvsasddktlkiwdvssgkclktlkghsnyvfccnfnpqsnlivsgsfd
esvriwdvktgkclktlpahsdpvsavhfnrdgslivsssydglcriwdtasgqclktli
ddnppvsfvkfspngkyilaatldntlklwdyskgkclktytghknekycifanfsvtgg
kwivsgsednlvyiwnlqtkeivqklqghtdvvistachpteniiasaalendktiklwk
sdc

  • Chain 'B':
    No sequence available.