PDB entry 3umx
View 3umx on RCSB PDB site
Description: Crystal structure of Pim1 kinase in complex with inhibitor (Z)-2-[(1H-indol-3-yl)methylene]-7-(azepan-1-ylmethyl)-6-hydroxybenzofuran-3(2H)-one
Class: transferase/inhibitor
Keywords: Pim-1, kinase, P-loop, kinase inhibitor, rational drug design, TRANSFERASE-INHIBITOR complex
Deposited on
2011-11-15, released
2012-08-08
The last revision prior to the SCOPe 2.06 freeze date was dated
2012-10-03, with a file datestamp of
2012-09-28.
Experiment type: XRAY
Resolution: 2.55 Å
R-factor: 0.18
AEROSPACI score: 0.34
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Proto-oncogene serine/threonine-protein kinase Pim-1
Species: Homo sapiens [TaxId:9606]
Gene: PIM1
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d3umxa_ - Heterogens: Q18, SO4, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3umxA (A:)
mkekeplesqyqvgpllgsggfgsvysgirvsdnlpvaikhvekdrisdwgelpngtrvp
mevvllkkvssgfsgvirlldwferpdsfvlilerpepvqdlfdfitergalqeelarsf
fwqvleavrhchncgvlhrdikdenilidlnrgelklidfgsgallkdtvytdfdgtrvy
sppewiryhryhgrsaavwslgillydmvcgdipfehdeeiirgqvffrqrvssecqhli
rwclalrpsdrptfeeiqnhpwmqdvllpqetaeihlhslspgpsksgpssgenlyfq
Sequence, based on observed residues (ATOM records): (download)
>3umxA (A:)
qyqvgpllgsggfgsvysgirvnlpvaikhvekdrisdwgervpmevvllkkvssgfsgv
irlldwferpdsfvlilerpepvqdlfdfitergalqeelarsffwqvleavrhchncgv
lhrdikdenilidlnrgelklidfgsgallkdtvytdfdgtrvysppewiryhryhgrsa
avwslgillydmvcgdipfehdeeiirgqvffrqrvssecqhlirwclalrpsdrptfee
iqnhpwmqdvllpqetaeihl