PDB entry 3uio

View 3uio on RCSB PDB site
Description: Complex between human RanGAP1-SUMO2, UBC9 and the IR1 domain from RanBP2 containing IR2 Motif II
Class: Ligase/Isomerase/Protein Binding
Keywords: E3, ligase, SUMO, UBC9, RanBP2, nuclear pore complex, Ligase-Isomerase-Protein Binding complex
Deposited on 2011-11-05, released 2011-12-28
The last revision prior to the SCOPe 2.03 freeze date was dated 2013-06-26, with a file datestamp of 2013-06-21.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.206
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: SUMO-conjugating enzyme UBC9
    Species: Homo sapiens [TaxId:9606]
    Gene: UBC9, UBCE9, UBE2I
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d3uioa_
  • Chain 'B':
    Compound: Small ubiquitin-related modifier 2
    Species: Homo sapiens [TaxId:9606]
    Gene: SMT3A, SMT3H2, SUMO2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61956 (Start-79)
      • see remark 999 (41)
    Domains in SCOPe 2.03: d3uiob_
  • Chain 'C':
    Compound: ran gtpase-activating protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: KIAA1835, RANGAP1, SD
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d3uioc_
  • Chain 'D':
    Compound: E3 SUMO-protein ligase RanBP2
    Species: Homo sapiens [TaxId:9606]
    Gene: NUP358, RANBP2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P49792 (2-End)
      • expression tag (1)
      • engineered mutation (13)
      • engineered mutation (15)
      • engineered mutation (18)
      • engineered mutation (20-21)
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3uioA (A:)
    msgialsrlaqerkawrkdhpfgfvavptknpdgtmnlmnwecaipgkkgtpwegglfkl
    rmlfkddypssppkckfepplfhpnvypsgtvclsileedkdwrpaitikqillgiqell
    nepniqdpaqaeaytiycqnrveyekrvraqakkfaps
    

    Sequence, based on observed residues (ATOM records): (download)
    >3uioA (A:)
    gialsrlaqerkawrkdhpfgfvavptknpdgtmnlmnwecaipgkkgtpwegglfklrm
    lfkddypssppkckfepplfhpnvypsgtvclsileedkdwrpaitikqillgiqellne
    pniqdpaqaeaytiycqnrveyekrvraqakkfaps
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >3uioB (B:)
    nndhinlkvagqdgsvvqfkikrhtplsklmkaycerqglsmrqirfrfdgqpinetdtp
    aqlemededtidvfqqqtgg
    

    Sequence, based on observed residues (ATOM records): (download)
    >3uioB (B:)
    ndhinlkvagqdgsvvqfkikrhtplsklmkaycerqglsmrqirfrfdgqpinetdtpa
    qlemededtidvfqqqtgg
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >3uioC (C:)
    sltgepapvlsspppadvstflafpspekllrlgpkssvliaqqtdtsdpekvvsaflkv
    ssvfkdeatvrmavqdavdalmqkafnsssfnsntfltrllvhmgllksedkvkaianly
    gplmalnhmvqqdyfpkalaplllafvtkpnsalescsfarhsllqtlykv
    

    Sequence, based on observed residues (ATOM records): (download)
    >3uioC (C:)
    advstflafpspekllrlgpkssvliaqqtdtsdpekvvsaflkvssvfkdeatvrmavq
    davdalmqkafnsssfnsntfltrllvhmgllksedkvkaianlygplmalnhmvqqdyf
    pkalaplllafvtkpnsalescsfarhsllqtlykv
    

  • Chain 'D':
    No sequence available.