PDB entry 3uio

View 3uio on RCSB PDB site
Description: Complex between human RanGAP1-SUMO2, UBC9 and the IR1 domain from RanBP2 containing IR2 Motif II
Class: Ligase/Isomerase/Protein Binding
Keywords: E3, ligase, SUMO, UBC9, RanBP2, nuclear pore complex, Ligase-Isomerase-Protein Binding complex
Deposited on 2011-11-05, released 2011-12-28
The last revision prior to the SCOPe 2.01 freeze date was dated 2012-01-04, with a file datestamp of 2011-12-30.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.206
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: SUMO-conjugating enzyme UBC9
    Species: Homo sapiens [TaxId:9606]
    Gene: UBC9, UBCE9, UBE2I
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d3uioa_
  • Chain 'B':
    Compound: Small ubiquitin-related modifier 2
    Species: Homo sapiens [TaxId:9606]
    Gene: SMT3A, SMT3H2, SUMO2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61956 (Start-79)
      • see remark 999 (41)
  • Chain 'C':
    Compound: ran gtpase-activating protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: KIAA1835, RANGAP1, SD
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d3uioc_
  • Chain 'D':
    Compound: E3 SUMO-protein ligase RanBP2
    Species: Homo sapiens [TaxId:9606]
    Gene: NUP358, RANBP2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P49792 (2-End)
      • expression tag (1)
      • engineered mutation (13)
      • engineered mutation (15)
      • engineered mutation (18)
      • engineered mutation (20-21)
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3uioA (A:)
msgialsrlaqerkawrkdhpfgfvavptknpdgtmnlmnwecaipgkkgtpwegglfkl
rmlfkddypssppkckfepplfhpnvypsgtvclsileedkdwrpaitikqillgiqell
nepniqdpaqaeaytiycqnrveyekrvraqakkfaps

    Sequence, based on observed residues (ATOM records): (download) 
    >3uioA (A:)
gialsrlaqerkawrkdhpfgfvavptknpdgtmnlmnwecaipgkkgtpwegglfklrm
lfkddypssppkckfepplfhpnvypsgtvclsileedkdwrpaitikqillgiqellne
pniqdpaqaeaytiycqnrveyekrvraqakkfaps

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3uioC (C:)
sltgepapvlsspppadvstflafpspekllrlgpkssvliaqqtdtsdpekvvsaflkv
ssvfkdeatvrmavqdavdalmqkafnsssfnsntfltrllvhmgllksedkvkaianly
gplmalnhmvqqdyfpkalaplllafvtkpnsalescsfarhsllqtlykv

    Sequence, based on observed residues (ATOM records): (download) 
    >3uioC (C:)
advstflafpspekllrlgpkssvliaqqtdtsdpekvvsaflkvssvfkdeatvrmavq
davdalmqkafnsssfnsntfltrllvhmgllksedkvkaianlygplmalnhmvqqdyf
pkalaplllafvtkpnsalescsfarhsllqtlykv

  • Chain 'D':
    No sequence available.