PDB entry 3uik

View 3uik on RCSB PDB site
Description: crystal structure of human Survivin mutant K62Y/H80W in complex with H3(1-10) peptide
Class: apoptosis/apoptosis inhibitor
Keywords: BIR domain, mitosis, T3 phosphorylated H3 binding, Smac/Diablo binding, APOPTOSIS-APOPTOSIS INHIBITOR complex
Deposited on 2011-11-04, released 2012-02-01
The last revision prior to the SCOPe 2.08 freeze date was dated 2012-02-01, with a file datestamp of 2012-01-27.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: 0.222
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Baculoviral IAP repeat-containing protein 5
    Species: Homo sapiens [TaxId:9606]
    Gene: BIRC5, API4, IAP4
    Database cross-references and differences (RAF-indexed):
    • Uniprot O15392
      • engineered mutation (62)
      • engineered mutation (80)
      • engineered mutation (129)
    Domains in SCOPe 2.08: d3uika_
  • Chain 'B':
    Compound: Baculoviral IAP repeat-containing protein 5
    Species: Homo sapiens [TaxId:9606]
    Gene: BIRC5, API4, IAP4
    Database cross-references and differences (RAF-indexed):
    • Uniprot O15392
      • engineered mutation (62)
      • engineered mutation (80)
      • engineered mutation (129)
    Domains in SCOPe 2.08: d3uikb_
  • Chain 'P':
    Compound: histone H3(1-10) peptide
    Database cross-references and differences (RAF-indexed):
    • PDB 3UIK (0-End)
  • Chain 'Q':
    Compound: histone H3(1-10) peptide
    Database cross-references and differences (RAF-indexed):
    • PDB 3UIK (0-End)
  • Heterogens: ZN

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3uikA (A:)
gmgaptlppawqpflkdhristfknwpflegcactpermaeagfihcptenepdlaqcff
cfyelegwepdddpieehkkwssgcaflsvkkqfeeltlgeflkldreraknkiaketnn
kkkefeetakkvrraieqlaamd

    Sequence, based on observed residues (ATOM records): (download) 
    >3uikA (A:)
tlppawqpflkdhristfknwpflegcactpermaeagfihcptenepdlaqcffcfyel
egwepdddpieehkkwssgcaflsvkkqfeeltlgeflkldreraknkiaketnnkkkef
eetakkvrraieqla

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3uikB (B:)
gmgaptlppawqpflkdhristfknwpflegcactpermaeagfihcptenepdlaqcff
cfyelegwepdddpieehkkwssgcaflsvkkqfeeltlgeflkldreraknkiaketnn
kkkefeetakkvrraieqlaamd

    Sequence, based on observed residues (ATOM records): (download) 
    >3uikB (B:)
tlppawqpflkdhristfknwpflegcactpermaeagfihcptenepdlaqcffcfyel
egwepdddpieehkkwssgcaflsvkkqfeeltlgeflkldreraknkiaketnnkkkef
eetakkvrraieqla

  • Chain 'P':
    No sequence available.

  • Chain 'Q':
    No sequence available.