PDB entry 3uii

View 3uii on RCSB PDB site
Description: crystal structure of human Survivin in complex with H3(1-10) peptide
Class: apoptosis/apoptosis inhibitor
Keywords: BIR domain, mitosis, T3 phosphorylated H3 binding, Smac/Diablo binding/H3 peptide, APOPTOSIS-APOPTOSIS INHIBITOR complex
Deposited on 2011-11-04, released 2012-02-01
The last revision prior to the SCOPe 2.06 freeze date was dated 2012-02-01, with a file datestamp of 2012-01-27.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.225
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Baculoviral IAP repeat-containing protein 5
    Species: Homo sapiens [TaxId:9606]
    Gene: BIRC5, API4, IAP4
    Database cross-references and differences (RAF-indexed):
    • Uniprot O15392
      • engineered mutation (129)
    Domains in SCOPe 2.06: d3uiia_
  • Chain 'B':
    Compound: Baculoviral IAP repeat-containing protein 5
    Species: Homo sapiens [TaxId:9606]
    Gene: BIRC5, API4, IAP4
    Database cross-references and differences (RAF-indexed):
    • Uniprot O15392
      • engineered mutation (129)
    Domains in SCOPe 2.06: d3uiib_
  • Chain 'P':
    Compound: histone H3(1-10) peptide
    Database cross-references and differences (RAF-indexed):
    • PDB 3UII (0-End)
  • Chain 'Q':
    Compound: histone H3(1-10) peptide
    Database cross-references and differences (RAF-indexed):
    • PDB 3UII (0-End)
  • Heterogens: ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3uiiA (A:)
gmgaptlppawqpflkdhristfknwpflegcactpermaeagfihcptenepdlaqcff
cfkelegwepdddpieehkkhssgcaflsvkkqfeeltlgeflkldreraknkiaketnn
kkkefeetakkvrraieqlaamd

    Sequence, based on observed residues (ATOM records): (download) 
    >3uiiA (A:)
tlppawqpflkdhristfknwpflegcactpermaeagfihcptenepdlaqcffcfkel
egwepdddpieehkkhssgcaflsvkkqfeeltlgeflkldreraknkiaketnnkkkef
eetakkvrraieqla

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3uiiB (B:)
gmgaptlppawqpflkdhristfknwpflegcactpermaeagfihcptenepdlaqcff
cfkelegwepdddpieehkkhssgcaflsvkkqfeeltlgeflkldreraknkiaketnn
kkkefeetakkvrraieqlaamd

    Sequence, based on observed residues (ATOM records): (download) 
    >3uiiB (B:)
tlppawqpflkdhristfknwpflegcactpermaeagfihcptenepdlaqcffcfkel
egwepdddpieehkkhssgcaflsvkkqfeeltlgeflkldreraknkiaketnnkkkef
eetakkvrraieqla

  • Chain 'P':
    No sequence available.

  • Chain 'Q':
    No sequence available.