PDB entry 3ug1

View 3ug1 on RCSB PDB site
Description: Crystal structure of the mutated EGFR kinase domain (G719S/T790M) in the apo form
Class: transferase
Keywords: kinase, tyrosine-protein kinase, transferase, ATP binding, phosphorylation, transmembrane, receptor, disease mutation, cell cycle, drug resistance
Deposited on 2011-11-02, released 2012-03-07
The last revision prior to the SCOPe 2.07 freeze date was dated 2014-03-12, with a file datestamp of 2014-03-07.
Experiment type: XRAY
Resolution: 2.75 Å
R-factor: 0.198
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533
      • engineered mutation (30)
      • engineered mutation (101)
    Domains in SCOPe 2.07: d3ug1a_
  • Heterogens: MES, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3ug1A (A:)
    gamgirsgeapnqallrilketefkkikvlssgafgtvykglwipegekvkipvaikelr
    eatspkankeildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdn
    igsqyllnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeeke
    yhaeggkvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissile
    kgerlpqppictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermh
    lpsptdsnfyralmdeedmddvvdadeylipqqg
    

    Sequence, based on observed residues (ATOM records): (download)
    >3ug1A (A:)
    eapnqallrilketefkkikvlssgtvykglwipegekvkipvaikespkankeildeay
    vmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnwcvqiakg
    mnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggkvpikwmale
    silhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppictidvy
    mimvkcwmidadsrpkfreliiefskmardpqrylviqgddeedmddvvdadeyli