PDB entry 3u88

View 3u88 on RCSB PDB site
Description: Crystal structure of human menin in complex with MLL1 and LEDGF
Class: transcription
Keywords: menin, MEN1, MLL, JunD, LEDGF, TPR, TRANSCRIPTION
Deposited on 2011-10-16, released 2012-02-15
The last revision prior to the SCOPe 2.06 freeze date was dated 2012-03-07, with a file datestamp of 2012-03-02.
Experiment type: XRAY
Resolution: 3 Å
R-factor: 0.205
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Menin
    Species: Homo sapiens [TaxId:9606]
    Gene: MEN1, SCG2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3u88a1, d3u88a2
  • Chain 'B':
    Compound: Menin
    Species: Homo sapiens [TaxId:9606]
    Gene: MEN1, SCG2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3u88b1, d3u88b2
  • Chain 'C':
    Compound: Lens epithelium-derived growth factor
    Species: Homo sapiens [TaxId:9606]
    Gene: DFS70, LEDGF, PSIP1, PSIP2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3u88c_
  • Chain 'D':
    Compound: Lens epithelium-derived growth factor
    Species: Homo sapiens [TaxId:9606]
    Gene: DFS70, LEDGF, PSIP1, PSIP2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3u88d_
  • Chain 'M':
    Compound: Histone-lysine N-methyltransferase MLL
    Species: Homo sapiens [TaxId:9606]
    Gene: ALL1, CXXC7, HRX, HTRX, KMT2A, MLL, MLL1, TRX1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q03164 (24-End)
      • expression tag (1-23)
  • Chain 'N':
    Compound: Histone-lysine N-methyltransferase MLL
    Species: Homo sapiens [TaxId:9606]
    Gene: ALL1, CXXC7, HRX, HTRX, KMT2A, MLL, MLL1, TRX1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q03164 (24-End)
      • expression tag (1-23)
  • Heterogens: CHD, 0BR, GGB, GLV, SO4

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3u88A (A:)
sglkaaqktlfplrsiddvvrlfaaelgreepdlvllslvlgfvehflavnrviptnvpe
ltfqpspapdppggltyfpvadlsiiaalyarftaqirgavdlslypreggvssrelvkk
vsdviwnslsrsyfkdrahiqslfsfitgtkldssgvafavvgacqalglrdvhlalsed
hawvvfgpngeqtaevtwhgkgnedrrgqtvnagvaerswlylkgsymrcdrkmevafmv
cainpsidlhtdslellqlqqkllwllydlghlerypmalgnladleeleptpgrpdplt
lyhkgiasaktyyrdehiypymylagyhcrnrnvrealqawadtatviqdynycredeei
ykeffevandvipnllkeaaslleageerpgeqsqgtqsqgsalqdpecfahllrfydgi
ckweegsptpvlhvgwatflvqslgrfegqvrqkvrivsgtvagtargpeggstaqvpap
taspppegpvltfqsekmkgmkellvatkinssaiklqltaqsqvqmkkqkvstpsdytl
sflkrqrkgl

    Sequence, based on observed residues (ATOM records): (download) 
    >3u88A (A:)
glkaaqktlfplrsiddvvrlfaaelgreepdlvllslvlgfvehflavnrviptnvpel
tfqpspapdggltyfpvadlsiiaalyarftaqirgavdlslypreggvssrelvkkvsd
viwnslsrsyfkdrahiqslfsfitgtkldssgvafavvgacqalglrdvhlalsedhaw
vvfgpngeqtaevtwhgkgnedrrgqtvnagvaerswlylkgsymrcdrkmevafmvcai
npsidlhtdslellqlqqkllwllydlghlerypmalgnladleeleptpgrpdpltlyh
kgiasaktyyrdehiypymylagyhcrnrnvrealqawadtatviqdynycredeeiyke
ffevandvipnllkeaaslleasalqdpecfahllrfydgickweegsptpvlhvgwatf
lvqslgrfegqvrqkvrivsegpvltfqsekmkgmkellvatkinssaiklqltaqs

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3u88B (B:)
sglkaaqktlfplrsiddvvrlfaaelgreepdlvllslvlgfvehflavnrviptnvpe
ltfqpspapdppggltyfpvadlsiiaalyarftaqirgavdlslypreggvssrelvkk
vsdviwnslsrsyfkdrahiqslfsfitgtkldssgvafavvgacqalglrdvhlalsed
hawvvfgpngeqtaevtwhgkgnedrrgqtvnagvaerswlylkgsymrcdrkmevafmv
cainpsidlhtdslellqlqqkllwllydlghlerypmalgnladleeleptpgrpdplt
lyhkgiasaktyyrdehiypymylagyhcrnrnvrealqawadtatviqdynycredeei
ykeffevandvipnllkeaaslleageerpgeqsqgtqsqgsalqdpecfahllrfydgi
ckweegsptpvlhvgwatflvqslgrfegqvrqkvrivsgtvagtargpeggstaqvpap
taspppegpvltfqsekmkgmkellvatkinssaiklqltaqsqvqmkkqkvstpsdytl
sflkrqrkgl

    Sequence, based on observed residues (ATOM records): (download) 
    >3u88B (B:)
glkaaqktlfplrsiddvvrlfaaelgreepdlvllslvlgfvehflavnrviptnvpel
tfqpspapdppggltyfpvadlsiiaalyarftaqirgavdlslypreggvssrelvkkv
sdviwnslsrsyfkdrahiqslfsfitgtkldssgvafavvgacqalglrdvhlalsedh
awvvfgpngeqtaevtwhgkgnedrrgqtvnagvaerswlylkgsymrcdrkmevafmvc
ainpsidlhtdslellqlqqkllwllydlghlerypmalgnladleeleptpgrpdpltl
yhkgiasaktyyrdehiypymylagyhcrnrnvrealqawadtatviqdynycredeeiy
keffevandvipnllkeaaslleagqgsalqdpecfahllrfydgickweegsptpvlhv
gwatflvqslgrfegqvrqkvrivsgpppegpvltfqsekmkgmkellvatkinssaikl
qltaq

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3u88C (C:)
smdsrlqrihaeiknslkidnldvnrciealdelaslqvtmqqaqkhtemittlkkirrf
kvsqvimekstmlynkfknmflvgegdsv

    Sequence, based on observed residues (ATOM records): (download) 
    >3u88C (C:)
mdsrlqrihaeiknslkidnldvnrciealdelaslqvtmqqaqkhtemittlkkirrfk
vsqvimekstmlynkfknmflv

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3u88D (D:)
smdsrlqrihaeiknslkidnldvnrciealdelaslqvtmqqaqkhtemittlkkirrf
kvsqvimekstmlynkfknmflvgegdsv

    Sequence, based on observed residues (ATOM records): (download) 
    >3u88D (D:)
qrihaeiknslvnrciealdelaslqvtmqqaqkhtemittlkkirqvimekstmlynkf
knmflvg

  • Chain 'M':
    No sequence available.

  • Chain 'N':
    No sequence available.