PDB entry 3u85

View 3u85 on RCSB PDB site
Description: Crystal structure of human menin in complex with MLL1
Class: transcription
Keywords: menin, MEN1, MLL, JunD, LEDGF, TPR, TRANSCRIPTION, epigenetics, cancer
Deposited on 2011-10-15, released 2012-02-15
The last revision prior to the SCOPe 2.06 freeze date was dated 2012-03-07, with a file datestamp of 2012-03-02.
Experiment type: XRAY
Resolution: 3 Å
R-factor: 0.224
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Menin
    Species: Homo sapiens [TaxId:9606]
    Gene: MEN1, SCG2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3u85a1, d3u85a2
  • Chain 'B':
    Compound: Histone-lysine N-methyltransferase MLL
    Species: Homo sapiens [TaxId:9606]
    Gene: ALL1, CXXC7, HRX, HTRX, KMT2A, MLL, MLL1, TRX1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q03164 (1-End)
      • expression tag (0)
    Domains in SCOPe 2.06: d3u85b1, d3u85b2

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3u85A (A:)
sglkaaqktlfplrsiddvvrlfaaelgreepdlvllslvlgfvehflavnrviptnvpe
ltfqpspapdppggltyfpvadlsiiaalyarftaqirgavdlslypreggvssrelvkk
vsdviwnslsrsyfkdrahiqslfsfitgtkldssgvafavvgacqalglrdvhlalsed
hawvvfgpngeqtaevtwhgkgnedrrgqtvnagvaerswlylkgsymrcdrkmevafmv
cainpsidlhtdslellqlqqkllwllydlghlerypmalgnladleeleptpgrpdplt
lyhkgiasaktyyrdehiypymylagyhcrnrnvrealqawadtatviqdynycredeei
ykeffevandvipnllkeaaslleageerpgeqsqgtqsqgsalqdpecfahllrfydgi
ckweegsptpvlhvgwatflvqslgrfegqvrqkvrivsgtvagtargpeggstaqvpap
taspppegpvltfqsekmkgmkellvatkinssaiklqltaqsqvqmkkqkvstpsdytl
sflkrqrkgl

    Sequence, based on observed residues (ATOM records): (download) 
    >3u85A (A:)
glkaaqktlfplrsiddvvrlfaaelgreepdlvllslvlgfvehflavnrviptnvpel
tfqpspapdppggltyfpvadlsiiaalyarftaqirgavdlslypreggvssrelvkkv
sdviwnslsrsyfkdrahiqslfsfitgtkldssgvafavvgacqalglrdvhlalsedh
awvvfgpngeqtaevtwhgkgnedrrgqtvnagvaerswlylkgsymrcdrkmevafmvc
ainpsidlhtdslellqlqqkllwllydlghlerypmalgnladleeleptpgrpdpltl
yhkgiasaktyyrdehiypymylagyhcrnrnvrealqawadtatviqdynycredeeiy
keffevandvipnllkeaaslleasalqdpecfahllrfydgickweegsptpvlhvgwa
tflvqslgrfegqvrqkvrivsgtvagtargpvltfqsekmkgmkellvatkinssaikl
qlta

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3u85B (B:)
srwrfparpgttgggggggrr

    Sequence, based on observed residues (ATOM records): (download) 
    >3u85B (B:)
srwrfparp