PDB entry 3u6j
View 3u6j on RCSB PDB site
Description: Crystal structure of the VEGFR2 kinase domain in complex with a pyrazolone inhibitor
Class: transferase/transferase inhibitor
Keywords: KDR, Flk-1, angiogenesis, phosphotransferase, cancer, vascular endothelial growth factor, TRANSFERASE/TRANSFERASE INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on
2011-10-12, released
2012-02-22
The last revision prior to the SCOPe 2.03 freeze date was dated
2012-05-23, with a file datestamp of
2012-05-18.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: 0.196
AEROSPACI score: 0.42
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Vascular endothelial growth factor receptor 2
Species: Homo sapiens [TaxId:9606]
Gene: FLK1, KDR
Database cross-references and differences (RAF-indexed):
- Uniprot P35968 (0-306)
- engineered mutation (101)
- engineered mutation (125)
- expression tag (307-309)
Domains in SCOPe 2.03: d3u6ja_ - Heterogens: 03X, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3u6jA (A:)
ehcerlpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtvavkmlkega
thsehralmselkilihighhlnvvnllgactkpggplmvitefckfgnlstylrskrne
fvpykvapedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvki
cdfglardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvllweifslgas
pypgvkideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnll
qanaqqdrhhhhhh
Sequence, based on observed residues (ATOM records): (download)
>3u6jA (A:)
ehcerlpydaskwefprdrlklgkplgrgafgqvieadafgidatcrtvavkmlkegath
sehralmselkilihighhlnvvnllgactkpggplmvitefckfgnlstylrskrnefv
pykvapedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvkicd
fglardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvllweifslgaspy
pgvkideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnllqa
naqqdrhh