PDB entry 3u5k

View 3u5k on RCSB PDB site
Description: Crystal Structure of the first bromodomain of human BRD4 in complex with Midazolam
Class: signaling protein/inhibitor
Keywords: Bromodomain-containing protein 4 isoform long, BRD4, Bromodomain containing protein 4, CAP, HUNK1, MCAP, Mitotic chromosome associated protein, Structural Genomics Consortium, SGC, SIGNALING PROTEIN-INHIBITOR complex
Deposited on 2011-10-11, released 2011-11-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2012-03-21, with a file datestamp of 2012-03-16.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.212
AEROSPACI score: 0.49 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bromodomain-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD4, HUNK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60885 (0-End)
      • cloning artifact (1)
    Domains in SCOPe 2.08: d3u5ka_
  • Chain 'B':
    Compound: Bromodomain-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD4, HUNK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60885
      • cloning artifact (1)
    Domains in SCOPe 2.08: d3u5kb1, d3u5kb2
  • Chain 'C':
    Compound: Bromodomain-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD4, HUNK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60885
      • cloning artifact (1)
    Domains in SCOPe 2.08: d3u5kc1, d3u5kc2
  • Chain 'D':
    Compound: Bromodomain-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD4, HUNK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60885 (0-End)
      • cloning artifact (1)
    Domains in SCOPe 2.08: d3u5kd_
  • Heterogens: 08J, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3u5kA (A:)
smnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykii
ktpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqki
nelptee

    Sequence, based on observed residues (ATOM records): (download) 
    >3u5kA (A:)
smnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykii
ktpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqki
nelpte

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3u5kB (B:)
smnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykii
ktpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqki
nelptee

    Sequence, based on observed residues (ATOM records): (download) 
    >3u5kB (B:)
mnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykiik
tpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqkin
elpt

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3u5kC (C:)
smnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykii
ktpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqki
nelptee

    Sequence, based on observed residues (ATOM records): (download) 
    >3u5kC (C:)
mnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykiik
tpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqkin
elp

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3u5kD (D:)
smnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykii
ktpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqki
nelptee

    Sequence, based on observed residues (ATOM records): (download) 
    >3u5kD (D:)
smnppppetsnpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykiiktp
mdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqkinel
pte