PDB entry 3u2o

View 3u2o on RCSB PDB site
Description: Dihydroorotate Dehydrogenase (DHODH) crystal structure in complex with small molecule inhibitor
Class: oxidoreductase/oxidoreductase inhibitor
Keywords: DHODH, DEHYDROGENASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Deposited on 2011-10-04, released 2011-11-16
The last revision prior to the SCOPe 2.07 freeze date was dated 2012-09-05, with a file datestamp of 2012-08-31.
Experiment type: XRAY
Resolution: 2.18 Å
R-factor: 0.161
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dihydroorotate dehydrogenase (quinone), mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: DHODH
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3u2oa_
  • Heterogens: FMN, ORO, 03U, ACT, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3u2oA (A:)
    mawrhlkkraqdaviilggggllfasylmatgderfyaehlmptlqglldpesahrlavr
    ftslgllprarfqdsdmlevrvlghkfrnpvgiaagfdkhgeavdglykmgfgfveigsv
    tpkpqegnprprvfrlpedqavinrygfnshglsvvehrlrarqqkqakltedglplgvn
    lgknktsvdaaedyaegvrvlgpladylvvnvsspntaglrslqgkaelrrlltkvlqer
    dglrrvhrpavlvkiapdltsqdkediasvvkelgidglivtnttvsrpaglqgalrset
    gglsgkplrdlstqtiremyaltqgrvpiigvggvssgqdalekiragaslvqlytaltf
    wgppvvgkvkreleallkeqgfggvtdaigadhrr
    

    Sequence, based on observed residues (ATOM records): (download)
    >3u2oA (A:)
    matgderfyaehlmptlqglldpesahrlavrftslgllprarfqdsdmlevrvlghkfr
    npvgiaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygf
    nshglsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladyl
    vvnvsspntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkedia
    svvkelgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvp
    iigvggvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtda
    igadhr