PDB entry 3tug
View 3tug on RCSB PDB site
Description: Crystal structure of the HECT domain of ITCH E3 ubiquitin ligase
Class: Ligase
Keywords: Structural Genomics, Structural Genomics Consortium, SGC, Catalytic domain, E3 Ligase, Ligase
Deposited on
2011-09-16, released
2011-10-12
The last revision prior to the SCOPe 2.08 freeze date was dated
2011-10-12, with a file datestamp of
2011-10-07.
Experiment type: XRAY
Resolution: 2.27 Å
R-factor: 0.198
AEROSPACI score: 0.39
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: E3 ubiquitin-protein ligase Itchy homolog
Species: Homo sapiens [TaxId:9606]
Gene: ITCH
Database cross-references and differences (RAF-indexed):
- Uniprot Q96J02
- engineered mutation (99)
- engineered mutation (295)
Domains in SCOPe 2.08: d3tuga_ - Heterogens: CL, UNX, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3tugA (A:)
mhhhhhhssgrenlyfqgyvrdfkakvqyfrfwcqqlampqhikitvtrktlfedsfqqi
msfspqdlrrrlwvifpgeegldyggvarewffllshevsnpmyclfeyagkdnyclqin
pasyinpdhlkyfrfigrfiamalfhgkfidtgfslpfykrilnkpvglkdlesidpefy
nsliwvkennieecdlemyfsvdkeilgeikshdlkpnggnilvteenkeeyirmvaewr
lsrgveeqtqaffegfneilpqqylqyfdakelevllcgmqeidlndwqrhaiyrryart
skqimwfwqfvkeidnekrmrllqfvtgtcrlpvggfadlmgsngpqkfciekvgkenwl
prshtcfnrldlppyksyeqlkekllfaieetegfgqe
Sequence, based on observed residues (ATOM records): (download)
>3tugA (A:)
vrdfkakvqyfrfwcqqlampqhikitvtrktlfedsfqqimsfspqdlrrrlwvifpge
egldyggvarewffllshevsnpmyclfeyayclqinpasyinpdhlkyfrfigrfiama
lfhgkfidtgfslpfykrilnkpvglkdlesidpefynsliwvkennyfskeeyirmvae
wrlsrgveeqtqaffegfneilpqqylqyfdakelevllcgmqeidlndwqrhaiyrrya
rtskqimwfwqfvkeidnekrmrllqfvtgtcrlpvggfadlmgsngpqkfciekvgken
wlprshtcfnrldlppyksyeqlkekllfaieet