PDB entry 3tug

View 3tug on RCSB PDB site
Description: Crystal structure of the HECT domain of ITCH E3 ubiquitin ligase
Class: Ligase
Keywords: Structural Genomics, Structural Genomics Consortium, SGC, Catalytic domain, E3 Ligase, Ligase
Deposited on 2011-09-16, released 2011-10-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-10-12, with a file datestamp of 2011-10-07.
Experiment type: XRAY
Resolution: 2.27 Å
R-factor: 0.198
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: E3 ubiquitin-protein ligase Itchy homolog
    Species: Homo sapiens [TaxId:9606]
    Gene: ITCH
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q96J02
      • engineered mutation (99)
      • engineered mutation (295)
    Domains in SCOPe 2.08: d3tuga_
  • Heterogens: CL, UNX, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3tugA (A:)
    mhhhhhhssgrenlyfqgyvrdfkakvqyfrfwcqqlampqhikitvtrktlfedsfqqi
    msfspqdlrrrlwvifpgeegldyggvarewffllshevsnpmyclfeyagkdnyclqin
    pasyinpdhlkyfrfigrfiamalfhgkfidtgfslpfykrilnkpvglkdlesidpefy
    nsliwvkennieecdlemyfsvdkeilgeikshdlkpnggnilvteenkeeyirmvaewr
    lsrgveeqtqaffegfneilpqqylqyfdakelevllcgmqeidlndwqrhaiyrryart
    skqimwfwqfvkeidnekrmrllqfvtgtcrlpvggfadlmgsngpqkfciekvgkenwl
    prshtcfnrldlppyksyeqlkekllfaieetegfgqe
    

    Sequence, based on observed residues (ATOM records): (download)
    >3tugA (A:)
    vrdfkakvqyfrfwcqqlampqhikitvtrktlfedsfqqimsfspqdlrrrlwvifpge
    egldyggvarewffllshevsnpmyclfeyayclqinpasyinpdhlkyfrfigrfiama
    lfhgkfidtgfslpfykrilnkpvglkdlesidpefynsliwvkennyfskeeyirmvae
    wrlsrgveeqtqaffegfneilpqqylqyfdakelevllcgmqeidlndwqrhaiyrrya
    rtskqimwfwqfvkeidnekrmrllqfvtgtcrlpvggfadlmgsngpqkfciekvgken
    wlprshtcfnrldlppyksyeqlkekllfaieet