PDB entry 3ttp

View 3ttp on RCSB PDB site
Description: Structure of multiresistant HIV-1 protease in complex with darunavir
Class: Hydrolase/hydrolase inhibitor
Keywords: hydrolase, viral praticle, Hydrolase-hydrolase inhibitor complex
Deposited on 2011-09-15, released 2012-09-26
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-02-26, with a file datestamp of 2020-02-21.
Experiment type: XRAY
Resolution: 2.23 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: hiv-1 protease
  Species: Human immunodeficiency virus type 1 [TaxId:11686]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P03367 (0-98)
    • engineered mutation (12)
    • engineered mutation (19)
    • engineered mutation (31-32)
    • engineered mutation (34-36)
    • engineered mutation (40)
    • engineered mutation (42)
    • engineered mutation (46)
    • engineered mutation (53)
    • engineered mutation (61-62)
    • engineered mutation (70-73)
    • engineered mutation (81)
    • engineered mutation (88)
    • engineered mutation (92)
  Domains in SCOPe 2.08: d3ttpa_
• Chain 'B':
  Compound: hiv-1 protease
  Species: Human immunodeficiency virus type 1 [TaxId:11686]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P03367 (0-98)
    • engineered mutation (12)
    • engineered mutation (19)
    • engineered mutation (31-32)
    • engineered mutation (34-36)
    • engineered mutation (40)
    • engineered mutation (42)
    • engineered mutation (46)
    • engineered mutation (53)
    • engineered mutation (61-62)
    • engineered mutation (70-73)
    • engineered mutation (81)
    • engineered mutation (88)
    • engineered mutation (92)
  Domains in SCOPe 2.08: d3ttpb_
• Heterogens: 017, CL, BME, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >3ttpA (A:)
  pqitlwqrplvtvkiggqlrealldtgaddtifedinlpgkwtpkmvggiggfmkvrqyd
  qvvieicghkvtspvlvgptplniigrnvltqlgctlnf
  

  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >3ttpB (B:)
  pqitlwqrplvtvkiggqlrealldtgaddtifedinlpgkwtpkmvggiggfmkvrqyd
  qvvieicghkvtspvlvgptplniigrnvltqlgctlnf