PDB entry 3ttj

View 3ttj on RCSB PDB site
Description: Crystal Structure of JNK3 complexed with CC-359, a JNK inhibitor for the prevention of ischemia-reperfusion injury
Class: transferase/transferase inhibitor
Keywords: Mitogen-Activated Protein Kinase 10, jnk3, Protein Kinase Inhibitors, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2011-09-14, released 2012-01-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2012-02-08, with a file datestamp of 2012-02-03.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.206
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mitogen-activated protein kinase 10
    Species: Homo sapiens [TaxId:9606]
    Gene: MAPK10, JNK3, JNK3A, PRKM10
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3ttja_
  • Heterogens: JBI, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3ttjA (A:)
mslhflyycseptldvkiafcqgfdkqvdvsyiakhynmskskvdnqfysvevgdstftv
lkryqnlkpigsgaqgivcaaydavldrnvaikklsrpfqnqthakrayrelvlmkcvnh
kniisllnvftpqktleefqdvylvmelmdanlcqviqmeldhermsyllyqmlcgikhl
hsagiihrdlkpsnivvksdctlkildfglartagtsfmmtpyvvtryyrapevilgmgy
kenvdiwsvgcimgemvrhkilfpgrdyidqwnkvieqlgtpcpefmkklqptvrnyven
rpkyagltfpklfpdslfpadsehnklkasqardllskmlvidpakrisvddalqhpyin
vwydpaeveapppqiydkqlderehtieewkeliykevmnseektkngvvkgqpspsgaa
vnsseslppsssvndissmstdqtlasdtdssleasagplgccr

    Sequence, based on observed residues (ATOM records): (download) 
    >3ttjA (A:)
nqfysvevstftvlkryqnlkpigsgaqgivcaaydavldrnvaikklsrpfqnqthakr
ayrelvlmkcvnhkniisllnvftpqktleefqdvylvmelmdanlcqviqmeldherms
yllyqmlcgikhlhsagiihrdlkpsnivvksdctlkildfglasfmmvtryyrapevil
gmgykenvdiwsvgcimgemvrhkilfpgrdyidqwnkvieqlgtpcpefmkklqptvrn
yvenrpkyagltfpklfpdslfpadsehnklkasqardllskmlvidpakrisvddalqh
pyinvwydpaeveappehtieewkeliykevmn