PDB entry 3tro

View 3tro on RCSB PDB site
Description: Crystal Structure of Leishmania major dihydroorotate dehydrogenase mutant D171A
Class: oxidoreductase
Keywords: pyrd, DHODH, LmDHODH, OXIDOREDUCTASE
Deposited on 2011-09-09, released 2012-09-12
The last revision prior to the SCOPe 2.04 freeze date was dated 2012-09-12, with a file datestamp of 2012-09-07.
Experiment type: XRAY
Resolution: 1.86 Å
R-factor: 0.182
AEROSPACI score: 0.48 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dihydroorotate dehydrogenase
    Species: Leishmania major [TaxId:347515]
    Gene: DHODH, lmjf16.0530, LMJF_16_0530
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q4QEW7 (34-End)
      • expression tag (32-33)
      • engineered mutation (204)
    Domains in SCOPe 2.04: d3troa_
  • Chain 'B':
    Compound: dihydroorotate dehydrogenase
    Species: Leishmania major [TaxId:347515]
    Gene: DHODH, lmjf16.0530, LMJF_16_0530
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q4QEW7 (34-End)
      • expression tag (32-33)
      • engineered mutation (204)
    Domains in SCOPe 2.04: d3trob_
  • Heterogens: FMN, SO4, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3troA (A:)
mgsshhhhhhssglvprgshmasmtggqqmgrgsmslqvnllnntfanpfmnaagvmctt
teelvamtesasgslvsksctpalregnptpryqalplgsinsmglpnngfdfylayaae
qhdygkkplflsmsglsmrenvemckrlaavatekgvilelnlscpnvpgkpqvaydfda
mrqcltavsevyphsfgvkmppyfafahfdaaaeilnefpkvqfitcinsignglvidae
tesvvikpkqgfgglggryvlptalaninafyrrcpgklifgcggvytgedaflhvlaga
smvqvgtalqeegpsiferltsellgvmakkryqtldefrgkvrtldgtaestr

    Sequence, based on observed residues (ATOM records): (download) 
    >3troA (A:)
gsmslqvnllnntfanpfmnaagvmcttteelvamtesasgslvsksctpalregnptpr
yqalplgsinsmglpnngfdfylayaaeqhdygkkplflsmsglsmrenvemckrlaava
tekgvilelnlspqvaydfdamrqcltavsevyphsfgvkmppyfafahfdaaaeilnef
pkvqfitcinsignglvidaetesvvikpkqgfgglggryvlptalaninafyrrcpgkl
ifgcggvytgedaflhvlagasmvqvgtalqeegpsiferltsellgvmakkryqtldef
rgkvrtl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3troB (B:)
mgsshhhhhhssglvprgshmasmtggqqmgrgsmslqvnllnntfanpfmnaagvmctt
teelvamtesasgslvsksctpalregnptpryqalplgsinsmglpnngfdfylayaae
qhdygkkplflsmsglsmrenvemckrlaavatekgvilelnlscpnvpgkpqvaydfda
mrqcltavsevyphsfgvkmppyfafahfdaaaeilnefpkvqfitcinsignglvidae
tesvvikpkqgfgglggryvlptalaninafyrrcpgklifgcggvytgedaflhvlaga
smvqvgtalqeegpsiferltsellgvmakkryqtldefrgkvrtldgtaestr

    Sequence, based on observed residues (ATOM records): (download) 
    >3troB (B:)
gsmslqvnllnntfanpfmnaagvmcttteelvamtesasgslvsksctpalregnptpr
yqalplgsinsmglpnngfdfylayaaeqhdygkkplflsmsglsmrenvemckrlaava
tekgvilelnlspqvaydfdamrqcltavsevyphsfgvkmppyfafahfdaaaeilnef
pkvqfitcinsignglvidaetesvvikpkqgfgglggryvlptalaninafyrrcpgkl
ifgcggvytgedaflhvlagasmvqvgtalqeegpsiferltsellgvmakkryqtldef
rgkvrtl