PDB entry 3tpr

View 3tpr on RCSB PDB site
Description: Crystal structure of BACE1 complexed with an inhibitor
Class: hydrolase/hydrolase inhibitor
Keywords: MEMAPSIN 2, PROTEASE, Beta-secretase 1, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2011-09-08, released 2011-11-23
The last revision prior to the SCOPe 2.04 freeze date was dated 2012-06-13, with a file datestamp of 2012-06-08.
Experiment type: XRAY
Resolution: 2.55 Å
R-factor: 0.231
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Beta-secretase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: BACE, BACE1, KIAA1149
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d3tpra_
  • Heterogens: 5HA, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3tprA (A:)
mgsshhhhhhsagenlyfqgtlpretdeepeepgrrgsfvemvdnlrgksgqgyyvemtv
gsppqtlnilvdtgssnfavgaaphpflhryyqrqlsstyrdlrkgvyvpytqgkwegel
gtdlvsiphgpnvtvraniaaitesdkffingsnwegilglayaeiarpddslepffdsl
vkqthvpnlfslqlcgagfplnqsevlasvggsmiiggidhslytgslwytpirrewyye
viivrveingqdlkmdckeynydksivdsgttnlrlpkkvfeaavksikaasstekfpdg
fwlgeqlvcwqagttpwnifpvislylmgevtnqsfritilpqqylrpvedvatsqddcy
kfaisqsstgtvmgavimegfyvvfdrarkrigfavsachvhdefrtaavegpfvtldme
dcgynipqtdest

    Sequence, based on observed residues (ATOM records): (download) 
    >3tprA (A:)
fvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqlss
tyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwegi
lglayaeiarpddslepffdslvkqthvpnlfslqlcgaasvggsmiiggidhslytgsl
wytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvfeaavksi
kaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfritilpqqylrp
vddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsachvhdefrtaavegpfv
tldmedcgyni