PDB entry 3tpp

View 3tpp on RCSB PDB site
Description: Crystal structure of BACE1 complexed with an inhibitor
Class: hydrolase/hydrolase inhibitor
Keywords: MEMAPSIN 2, PROTEASE, BACE1, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2011-09-08, released 2011-11-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-08, with a file datestamp of 2017-11-03.
Experiment type: XRAY
Resolution: 1.6 Å
R-factor: N/A
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Beta-secretase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: BACE, BACE1, KIAA1149
    Database cross-references and differences (RAF-indexed):
    • Uniprot P56817
      • engineered mutation (114)
      • engineered mutation (116)
    Domains in SCOPe 2.08: d3tppa_
  • Heterogens: 5HA, CL, URE, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3tppA (A:)
mgsshhhhhhsagenlyfqgtlpretdeepeepgrrgsfvemvdnlrgksgqgyyvemtv
gsppqtlnilvdtgssnfavgaaphpflhryyqrqlsstyrdlrkgvyvpytqgawagel
gtdlvsiphgpnvtvraniaaitesdkffingsnwegilglayaeiarpddslepffdsl
vkqthvpnlfslqlcgagfplnqsevlasvggsmiiggidhslytgslwytpirrewyye
viivrveingqdlkmdckeynydksivdsgttnlrlpkkvfeaavksikaasstekfpdg
fwlgeqlvcwqagttpwnifpvislylmgevtnqsfritilpqqylrpvedvatsqddcy
kfaisqsstgtvmgavimegfyvvfdrarkrigfavsachvhdefrtaavegpfvtldme
dcgynipqtdest

    Sequence, based on observed residues (ATOM records): (download) 
    >3tppA (A:)
rgsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrq
lsstyrdlrkgvyvpytqgawagelgtdlvsiphgpnvtvraniaaitesdkffingsnw
egilglayaeiarpddslepffdslvkqthvpnlfslqlcgavggsmiiggidhslytgs
lwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvfeaavks
ikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfritilpqqylr
pvetsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsachvhdefrtaav
egpfvtldmedcgyn