PDB entry 3tn8
View 3tn8 on RCSB PDB site
Description: CDK9/cyclin T in complex with CAN508
Class: transferase/transferase inhibitor
Keywords: cyclin dependent kinase, Kinase, cyclin, phosphotransfer, CDK-cyclin complex, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on
2011-09-01, released
2012-02-15
The last revision prior to the SCOPe 2.06 freeze date was dated
2012-06-13, with a file datestamp of
2012-06-08.
Experiment type: XRAY
Resolution: 2.95 Å
R-factor: 0.179
AEROSPACI score: 0.28
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Cyclin-dependent kinase 9
Species: Homo sapiens [TaxId:9606]
Gene: CDC2L4, CDK9
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d3tn8a_ - Chain 'B':
Compound: Cyclin-T1
Species: Homo sapiens [TaxId:9606]
Gene: CCNT1
Database cross-references and differences (RAF-indexed):
- Uniprot O60563 (Start-259)
- engineered mutation (77)
- engineered mutation (96)
- engineered mutation (241)
Domains in SCOPe 2.06: d3tn8b1, d3tn8b2 - Heterogens: GOL, PO4, F18, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3tn8A (A:)
gpakqydsvecpfcdevskyeklakigqgtfgevfkarhrktgqkvalkkvlmenekegf
pitalreikilqllkhenvvnlieicrtkaspynrckgsiylvfdfcehdlagllsnvlv
kftlseikrvmqmllnglyyihrnkilhrdmkaanvlitrdgvlkladfglarafslakn
sqpnrytnrvvtlwyrppelllgerdygppidlwgagcimaemwtrspimqgnteqhqla
lisqlcgsitpevwpnvdnyelyeklelvkgqkrkvkdrlkayvrdpyaldlidkllvld
paqridsddalnhdffwsdpmpsdlkgmlst
Sequence, based on observed residues (ATOM records): (download)
>3tn8A (A:)
vecpfcdevskyeklakigqgtfgevfkarhrktgqkvalkkvlmenekegfpitalrei
kilqllkhenvvnlieicrtgsiylvfdfcehdlagllsnvlvkftlseikrvmqmllng
lyyihrnkilhrdmkaanvlitrdgvlkladfglarafslqpnrytnrvvtlwyrppell
lgerdygppidlwgagcimaemwtrspimqgnteqhqlalisqlcgsitpevwpnvdnye
lyeklelvkgqkrkvkdrlkayvrdpyaldlidkllvldpaqridsddalnhdffwsdpm
psdlk
- Chain 'B':
Sequence, based on SEQRES records: (download)
>3tn8B (B:)
gpegerknnnkrwyftreqlenspsrrfgvdpdkelsyrqqaanllqdmgqrlnvsqlti
ntaivymhrfymiqsftrfpgnsvapaalflaakvegqpkklehvikvahtclhpqeslp
dtrseaylqqvqdlvilesiilqtlgfeltidhphthvvkctqlvraskdlaqtsyfmat
nslhlttfslqytppvvacvcihlackwsnweipvstdgkhwweyvdatvtlelldelth
ellqilektpnrlkriwnwr
Sequence, based on observed residues (ATOM records): (download)
>3tn8B (B:)
nnkrwyftreqlenspsrrfgvdpdkelsyrqqaanllqdmgqrlnvsqltintaivymh
rfymiqsftrfpgnsvapaalflaakvegqpkklehvikvahtclhpqeslpdtrseayl
qqvqdlvilesiilqtlgfeltidhphthvvkctqlvraskdlaqtsyfmatnslhlttf
slqytppvvacvcihlackwsnweipvstdgkhwweyvdatvtlelldelthellqilek
tpnrlkriwnwr