PDB entry 3tn8

View 3tn8 on RCSB PDB site
Description: CDK9/cyclin T in complex with CAN508
Class: transferase/transferase inhibitor
Keywords: cyclin dependent kinase, Kinase, cyclin, phosphotransfer, CDK-cyclin complex, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2011-09-01, released 2012-02-15
The last revision prior to the SCOPe 2.05 freeze date was dated 2012-06-13, with a file datestamp of 2012-06-08.
Experiment type: XRAY
Resolution: 2.95 Å
R-factor: 0.179
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cyclin-dependent kinase 9
    Species: Homo sapiens [TaxId:9606]
    Gene: CDC2L4, CDK9
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d3tn8a_
  • Chain 'B':
    Compound: Cyclin-T1
    Species: Homo sapiens [TaxId:9606]
    Gene: CCNT1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60563 (Start-259)
      • engineered mutation (77)
      • engineered mutation (96)
      • engineered mutation (241)
    Domains in SCOPe 2.05: d3tn8b1, d3tn8b2
  • Heterogens: GOL, PO4, F18, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3tn8A (A:)
gpakqydsvecpfcdevskyeklakigqgtfgevfkarhrktgqkvalkkvlmenekegf
pitalreikilqllkhenvvnlieicrtkaspynrckgsiylvfdfcehdlagllsnvlv
kftlseikrvmqmllnglyyihrnkilhrdmkaanvlitrdgvlkladfglarafslakn
sqpnrytnrvvtlwyrppelllgerdygppidlwgagcimaemwtrspimqgnteqhqla
lisqlcgsitpevwpnvdnyelyeklelvkgqkrkvkdrlkayvrdpyaldlidkllvld
paqridsddalnhdffwsdpmpsdlkgmlst

    Sequence, based on observed residues (ATOM records): (download) 
    >3tn8A (A:)
vecpfcdevskyeklakigqgtfgevfkarhrktgqkvalkkvlmenekegfpitalrei
kilqllkhenvvnlieicrtgsiylvfdfcehdlagllsnvlvkftlseikrvmqmllng
lyyihrnkilhrdmkaanvlitrdgvlkladfglarafslqpnrytnrvvtlwyrppell
lgerdygppidlwgagcimaemwtrspimqgnteqhqlalisqlcgsitpevwpnvdnye
lyeklelvkgqkrkvkdrlkayvrdpyaldlidkllvldpaqridsddalnhdffwsdpm
psdlk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3tn8B (B:)
gpegerknnnkrwyftreqlenspsrrfgvdpdkelsyrqqaanllqdmgqrlnvsqlti
ntaivymhrfymiqsftrfpgnsvapaalflaakvegqpkklehvikvahtclhpqeslp
dtrseaylqqvqdlvilesiilqtlgfeltidhphthvvkctqlvraskdlaqtsyfmat
nslhlttfslqytppvvacvcihlackwsnweipvstdgkhwweyvdatvtlelldelth
ellqilektpnrlkriwnwr

    Sequence, based on observed residues (ATOM records): (download) 
    >3tn8B (B:)
nnkrwyftreqlenspsrrfgvdpdkelsyrqqaanllqdmgqrlnvsqltintaivymh
rfymiqsftrfpgnsvapaalflaakvegqpkklehvikvahtclhpqeslpdtrseayl
qqvqdlvilesiilqtlgfeltidhphthvvkctqlvraskdlaqtsyfmatnslhlttf
slqytppvvacvcihlackwsnweipvstdgkhwweyvdatvtlelldelthellqilek
tpnrlkriwnwr