PDB entry 3tmz

View 3tmz on RCSB PDB site
Description: Crystal Structure of P450 2B4(H226Y) in complex with Amlodipine
Class: oxidoreductase
Keywords: P450, cytochrome P450 2B4, monooxygenase, oxidoreductase, membrane protein, CYP 2B4,
Deposited on 2011-09-01, released 2012-09-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2012-10-03, with a file datestamp of 2012-09-28.
Experiment type: XRAY
Resolution: 2.25 Å
R-factor: 0.194
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cytochrome P450 2B4
    Species: Oryctolagus cuniculus [TaxId:9986]
    Gene: CYP2B4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00178 (Start-471)
      • engineered mutation (9)
      • see remark 999 (201)
      • engineered mutation (206)
      • expression tag (472)
    Domains in SCOPe 2.08: d3tmza1, d3tmza2
  • Heterogens: HEM, CM5, 06X, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3tmzA (A:)
makktsskgklppgpsplpvlgnllqmdrkgllrsflrlrekygdvftvylgsrpvvvlc
gtdairealvdqaeafsgrgkiavvdpifqgygvifangerwralrrfslatmrdfgmgk
rsveeriqeearclveelrkskgalldntllfhsitsniicsivfgkrfdykdpvflrll
dlffqsfslissfssqvfelfsgflkyfpgthrqiyrnlqeintfigqsvekhratldps
nprdfidvyllrmekdksdpssefhhqnliltvlslffagtettsttlrygfllmlkyph
vtervqkeieqvigshrppalddrakmpytdaviheiqrlgdlipfgvphtvtkdtqfrg
yvipkntevfpvlssalhdpryfetpntfnpghfldangalkrnegfmpfslgkriclge
giartelflffttilqnfsiaspvppedidltpresgvgnvppsyqirflarhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3tmzA (A:)
gklppgpsplpvlgnllqmdkgllrsflrlrekygdvftvylgsrpvvvlcgtdaireal
vdqaeafsgrgkiavvdpifqgygvifangerwralrrfslatmrdfmgkrsveeriqee
arclveelrkskgalldntllfhsitsniicsivfgkrfdykdpvflrlldlffqsfsli
ssfssqvfelfsgflkyfpgthrqiyrnlqeintfigqsvekhratldpsnprdfidvyl
lrmekdksdpssefhhqnliltvlslffagtettsttlrygfllmlkyphvtervqkeie
qvigshrppalddrakmpytdaviheiqrlgdlipfgvphtvtkdtqfrgyvipkntevf
pvlssalhdpryfetpntfnpghfldangalkrnegfmpfslgkriclgegiartelflf
fttilqnfsiaspvppedidltpresgvgnvppsyqirflarh