PDB entry 3tjd

View 3tjd on RCSB PDB site
Description: co-crystal structure of Jak2 with thienopyridine 19
Class: transferase/transferase inhibitor
Keywords: jak2, kinase, inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2011-08-24, released 2011-11-30
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-12-28, with a file datestamp of 2011-12-23.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: 0.286
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase JAK2
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3tjda_
  • Chain 'B':
    Compound: Tyrosine-protein kinase JAK2
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3tjdb_
  • Heterogens: 6TP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3tjdA (A:)
gsedrdptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrd
fereieilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhikll
qytsqickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepg
espifwyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmi
vfhliellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnmag

    Sequence, based on observed residues (ATOM records): (download) 
    >3tjdA (A:)
qfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdfereieil
kslqhdnivkykgvcysnlklimeylpygslrdylqkhkeridhikllqytsqickgmey
lgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepgespifwyapesl
teskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivfhliellknng
rlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnmag

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3tjdB (B:)
gsedrdptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrd
fereieilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhikll
qytsqickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepg
espifwyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmi
vfhliellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnmag

    Sequence, based on observed residues (ATOM records): (download) 
    >3tjdB (B:)
dptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdferei
eilkslqhdnivkykgvcysnlklimeylpygslrdylqkhkeridhikllqytsqickg
meylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepgespifwyap
eslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivfhliellk
nngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnmag