PDB entry 3ti6

View 3ti6 on RCSB PDB site
Description: Crystal structure of 2009 pandemic H1N1 neuraminidase complexed with oseltamivir
Class: hydrolase/hydrolase inhibitor
Keywords: 6-BLADED BETA-PROPELLER, Calcium Binding, Glycosylation, antiviral, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2011-08-20, released 2011-11-23
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-11-23, with a file datestamp of 2011-11-18.
Experiment type: XRAY
Resolution: 1.69 Å
R-factor: 0.141
AEROSPACI score: 0.59 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Neuraminidase
    Species: Influenza A virus [TaxId:641501]
    Gene: NA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d3ti6a_
  • Chain 'B':
    Compound: Neuraminidase
    Species: Influenza A virus [TaxId:641501]
    Gene: NA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d3ti6b_
  • Heterogens: NAG, CA, G39, GOL, ACT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3ti6A (A:)
    svklagnsslcpvsgwaiyskdnsvrigskgdvfvirepfiscsplecrtffltqgalln
    dkhsngtikdrspyrtlmscpigevpspynsrfesvawsasachdginwltigisgpdng
    avavlkyngiitdtikswrnnilrtqesecacvngscftvmtdgpsngqasykifriekg
    kivksvemnapnyhyeecscypdsseitcvcrdnwhgsnrpwvsfnqnleyqigyicsgi
    fgdnprpndktgscgpvssngangvkgfsfkygngvwigrtksissrngfemiwdpngwt
    gtdnnfsikqdivginewsgysgsfvqhpeltgldcirpcfwvelirgrpkentiwtsgs
    sisfcgvnsdtvgwswpdgaelpftidk
    

    Sequence, based on observed residues (ATOM records): (download)
    >3ti6A (A:)
    svklagnsslcpvsgwaiyskdnsvrigskgdvfvirepfiscsplecrtffltqgalln
    dkhsngtikdrspyrtlmscpigevpspynsrfesvawsasachdginwltigisgpdng
    avavlkyngiitdtikswrnnilrtqesecacvngscftvmtdgpsngqasykifriekg
    kivksvemnapnyhyeecscypdsseitcvcrdnwhgsnrpwvsfnqnleyqigyicsgi
    fgdnprpndktgscgpvssngangvkgfsfkygngvwigrtksissrngfemiwdpngwt
    gtdnnfsikqdivginewsgysgsfvqhpeltgldcirpcfwvelirgrpkentiwtsgs
    sisfcgvnsdtvgwswpdgaelpftid
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >3ti6B (B:)
    svklagnsslcpvsgwaiyskdnsvrigskgdvfvirepfiscsplecrtffltqgalln
    dkhsngtikdrspyrtlmscpigevpspynsrfesvawsasachdginwltigisgpdng
    avavlkyngiitdtikswrnnilrtqesecacvngscftvmtdgpsngqasykifriekg
    kivksvemnapnyhyeecscypdsseitcvcrdnwhgsnrpwvsfnqnleyqigyicsgi
    fgdnprpndktgscgpvssngangvkgfsfkygngvwigrtksissrngfemiwdpngwt
    gtdnnfsikqdivginewsgysgsfvqhpeltgldcirpcfwvelirgrpkentiwtsgs
    sisfcgvnsdtvgwswpdgaelpftidk
    

    Sequence, based on observed residues (ATOM records): (download)
    >3ti6B (B:)
    svklagnsslcpvsgwaiyskdnsvrigskgdvfvirepfiscsplecrtffltqgalln
    dkhsngtikdrspyrtlmscpigevpspynsrfesvawsasachdginwltigisgpdng
    avavlkyngiitdtikswrnnilrtqesecacvngscftvmtdgpsngqasykifriekg
    kivksvemnapnyhyeecscypdsseitcvcrdnwhgsnrpwvsfnqnleyqigyicsgi
    fgdnprpndktgscgpvssngangvkgfsfkygngvwigrtksissrngfemiwdpngwt
    gtdnnfsikqdivginewsgysgsfvqhpeltgldcirpcfwvelirgrpkentiwtsgs
    sisfcgvnsdtvgwswpdgaelpftid