PDB entry 3thb

View 3thb on RCSB PDB site
Description: Structure of PLK1 kinase domain in complex with a benzolactam-derived inhibitor
Class: transferase/transferase inhibitor
Keywords: kinase domain, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2011-08-18, released 2011-11-23
The last revision prior to the SCOPe 2.06 freeze date was dated 2012-01-25, with a file datestamp of 2012-01-20.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.253
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein kinase PLK1
    Species: Homo sapiens [TaxId:9606]
    Gene: PLK1, PLK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P53350
      • engineered mutation (197)
    Domains in SCOPe 2.06: d3thba_
  • Heterogens: ZN, 3TA

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3thbA (A:)
apadpgkagvpgvaapgapaaappakeipevlvdprsrrryvrgrflgkggfakcfeisd
adtkevfagkivpkslllkphqrekmsmeisihrslahqhvvgfhgffedndfvfvvlel
crrrsllelhkrrkaltepearyylrqivlgcqylhrnrvihrdlklgnlflnedlevki
gdfglatkveydgerkkvlcgtpnyiapevlskkghsfevdvwsigcimytllvgkppfe
tsclketylrikkneysipkhinpvaasliqkmlqtdptarptinellndefftsgyipa
rlpitcltipprfsiapssldpsnrkpltvlnk

    Sequence, based on observed residues (ATOM records): (download) 
    >3thbA (A:)
evlvdprsrrryvrgrflgkggfakcfeisdadtkevfagkivpkslllkphqrekmsme
isihrslahqhvvgfhgffedndfvfvvlelcrrrsllelhkrrkaltepearyylrqiv
lgcqylhrnrvihrdlklgnlflnedlevkigdfglatkveydgerkkvlcgtpnyiape
vlskkghsfevdvwsigcimytllvgkppfetsclketylrikkneysipkhinpvaasl
iqkmlqtdptarptinellndefftsgyiparlpitcltipprfsia