PDB entry 3thb
View 3thb on RCSB PDB site
Description: Structure of PLK1 kinase domain in complex with a benzolactam-derived inhibitor
Class: transferase/transferase inhibitor
Keywords: kinase domain, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on
2011-08-18, released
2011-11-23
The last revision prior to the SCOPe 2.05 freeze date was dated
2012-01-25, with a file datestamp of
2012-01-20.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.253
AEROSPACI score: 0.27
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Serine/threonine-protein kinase PLK1
Species: Homo sapiens [TaxId:9606]
Gene: PLK1, PLK
Database cross-references and differences (RAF-indexed):
- Uniprot P53350
- engineered mutation (197)
Domains in SCOPe 2.05: d3thba_ - Heterogens: ZN, 3TA
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3thbA (A:)
apadpgkagvpgvaapgapaaappakeipevlvdprsrrryvrgrflgkggfakcfeisd
adtkevfagkivpkslllkphqrekmsmeisihrslahqhvvgfhgffedndfvfvvlel
crrrsllelhkrrkaltepearyylrqivlgcqylhrnrvihrdlklgnlflnedlevki
gdfglatkveydgerkkvlcgtpnyiapevlskkghsfevdvwsigcimytllvgkppfe
tsclketylrikkneysipkhinpvaasliqkmlqtdptarptinellndefftsgyipa
rlpitcltipprfsiapssldpsnrkpltvlnk
Sequence, based on observed residues (ATOM records): (download)
>3thbA (A:)
evlvdprsrrryvrgrflgkggfakcfeisdadtkevfagkivpkslllkphqrekmsme
isihrslahqhvvgfhgffedndfvfvvlelcrrrsllelhkrrkaltepearyylrqiv
lgcqylhrnrvihrdlklgnlflnedlevkigdfglatkveydgerkkvlcgtpnyiape
vlskkghsfevdvwsigcimytllvgkppfetsclketylrikkneysipkhinpvaasl
iqkmlqtdptarptinellndefftsgyiparlpitcltipprfsia