PDB entry 3th4

View 3th4 on RCSB PDB site
Description: Mg2+ Is Required for Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors At Physiological Ca2+
Class: hydrolase/hydrolase inhibitor
Keywords: Hydrolase, Serine Protease, Blood Clotting, Soluble Tissue Factor, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2011-08-18, released 2012-08-22
The last revision prior to the SCOPe 2.07 freeze date was dated 2015-04-08, with a file datestamp of 2015-04-03.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: N/A
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: Coagulation factor VII heavy chain
    Species: Homo sapiens [TaxId:9606]
    Gene:
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3th4h_
  • Chain 'L':
    Compound: Coagulation factor VII light chain
    Species: Homo sapiens [TaxId:9606]
    Gene:
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3th4l1, d3th4l2, d3th4l3
  • Chain 'T':
    Compound: tissue factor
    Species: Homo sapiens [TaxId:9606]
    Gene:
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3th4t1, d3th4t2
  • Heterogens: BGC, FUC, MG, CA, 0GE, NA, CL, HOH

PDB Chain Sequences:

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3th4H (H:)
    ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
    lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
    lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrkvgdspniteymfcagy
    sdgskdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmr
    seprpgvllrapfp
    

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3th4L (L:)
    anafleelrpgslereckeeqcsfeeareifkdaertklfwisysdgdqcasspcqnggs
    ckdqlqsyicfclpafegrncethkddqlicvnenggceqycsdhtgtkrscrchegysl
    ladgvsctptveypcgkipile
    

  • Chain 'T':
    Sequence, based on SEQRES records: (download)
    >3th4T (T:)
    tvaaynltwkstnfktilewepkpvnqvytvqistksgdwkskcfyttdtecdltdeivk
    dvkqtylarvfsypagnvestgsageplyenspeftpyletnlgqptiqsfeqvgtkvnv
    tvedertlvrrnntflslrdvfgkdliytlyywkssssgkktaktntneflidvdkgeny
    cfsvqavipsrtvnrkstdspvecm
    

    Sequence, based on observed residues (ATOM records): (download)
    >3th4T (T:)
    tvaaynltwkstnfktilewepkpvnqvytvqistksgdwkskcfyttdtecdltdeivk
    dvkqtylarvfsypagngeplyenspeftpyletnlgqptiqsfeqvgtkvnvtvedert
    lvrrnntflslrdvfgkdliytlyywktaktntneflidvdkgenycfsvqavipsrtvn
    rkstdspvecm