PDB entry 3th3

View 3th3 on RCSB PDB site
Description: Mg2+ Is Required for Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors At Physiological Ca2+
Class: hydrolase/hydrolase inhibitor
Keywords: HYDROLASE, BLOOD CLOTTING, SERINE PROTEASE, BLOOD COAGULATION, Soluble Tissue Factor, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2011-08-18, released 2012-08-22
The last revision prior to the SCOPe 2.07 freeze date was dated 2012-08-22, with a file datestamp of 2012-08-17.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: 0.232
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: Coagulation factor VII heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3th3h_
  • Chain 'L':
    Compound: Coagulation factor VII light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3th3l1, d3th3l2
  • Chain 'T':
    Compound: tissue factor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3th3t1, d3th3t2
  • Heterogens: BGC, FUC, CA, 0GE, CL, HOH

PDB Chain Sequences:

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3th3H (H:)
ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrkvgdspniteymfcagy
sdgskdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmr
seprpgvllrapfp

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >3th3L (L:)
anafleelrpgslereckeeqcsfeeareifkdaertklfwisysdgdqcasspcqnggs
ckdqlqsyicfclpafegrncethkddqlicvnenggceqycsdhtgtkrscrchegysl
ladgvsctptveypcgkipile

    Sequence, based on observed residues (ATOM records): (download) 
    >3th3L (L:)
gdqcasspcqnggsckdqlqsyicfclpafegrncethkddqlicvnenggceqycsdht
gtkrscrchegyslladgvsctptveypcgkipile

  • Chain 'T':
    Sequence, based on SEQRES records: (download) 
    >3th3T (T:)
tvaaynltwkstnfktilewepkpvnqvytvqistksgdwkskcfyttdtecdltdeivk
dvkqtylarvfsypagnvestgsageplyenspeftpyletnlgqptiqsfeqvgtkvnv
tvedertlvrrnntflslrdvfgkdliytlyywkssssgkktaktntneflidvdkgeny
cfsvqavipsrtvnrkstdspvecm

    Sequence, based on observed residues (ATOM records): (download) 
    >3th3T (T:)
tvaaynltwkstnfktilewepkpvnqvytvqistksgdwkskcfyttdtecdltdeivk
dvkqtylarvfsypagngeplyenspeftpyletnlgqptrtlvrrnntflslrdvfgkd
liytktntnecfsvqavipsrtvnrkstdspvec