PDB entry 3tct
View 3tct on RCSB PDB site
Description: Structure of wild-type TTR in complex with tafamidis
Class: hormone, binding protein
Keywords: AMYLOID, AMYLOIDOSIS, DISEASE MUTATION, GAMMA-CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, HORMONE, NEUROPATHY, SECRETED, THYROID HORMONE, TRANSPORT, Kinetic Stabilizer, Inhibition of the Amyloid Cascade, BINDING PROTEIN
Deposited on
2011-08-09, released
2012-05-30
The last revision prior to the SCOPe 2.08 freeze date was dated
2012-08-29, with a file datestamp of
2012-08-24.
Experiment type: XRAY
Resolution: 1.3 Å
R-factor: 0.163
AEROSPACI score: 0.76
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Transthyretin
Species: Homo sapiens [TaxId:9606]
Gene: PALB, TTR
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d3tcta_ - Chain 'B':
Compound: Transthyretin
Species: Homo sapiens [TaxId:9606]
Gene: PALB, TTR
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d3tctb_ - Heterogens: 3MI, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3tctA (A:)
gptgtgeskcplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltt
eeefvegiykveidtksywkalgispfhehaevvftandsgprrytiaallspysystta
vvtnpke
Sequence, based on observed residues (ATOM records): (download)
>3tctA (A:)
plmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltteeefvegiyk
veidtksywkalgispfhehaevvftandsgprrytiaallspysysttavvtnp
- Chain 'B':
Sequence, based on SEQRES records: (download)
>3tctB (B:)
gptgtgeskcplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltt
eeefvegiykveidtksywkalgispfhehaevvftandsgprrytiaallspysystta
vvtnpke
Sequence, based on observed residues (ATOM records): (download)
>3tctB (B:)
plmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltteeefvegiyk
veidtksywkalgispfhehaevvftandsgprrytiaallspysysttavvtn