PDB entry 3tc5

View 3tc5 on RCSB PDB site
Description: Selective targeting of disease-relevant protein binding domains by O-phosphorylated natural product derivatives
Class: isomerase/isomerase inhibitor
Keywords: PIN1 mutant (R14A), Oncogenic transformation, Small molecule, Cell cycle, Rotamase, Phosphoprotein, Nucleus, ISOMERASE-ISOMERASE INHIBITOR complex
Deposited on 2011-08-08, released 2011-08-31
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-08, with a file datestamp of 2017-11-03.
Experiment type: XRAY
Resolution: 1.4 Å
R-factor: N/A
AEROSPACI score: 0.53 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PIN1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13526 (Start-165)
      • engineered mutation (16)
    Domains in SCOPe 2.08: d3tc5a1, d3tc5a2
  • Heterogens: 3T5, P6G, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3tc5A (A:)
gshmadeeklppgwekamsrssgrvyyfnhitnasqwerpsgnsssggkngqgeparvrc
shllvkhsqsrrpsswrqekitrtkeealelingyiqkiksgeedfeslasqfsdcssak
argdlgafsrgqmqkpfedasfalrtgemsgpvftdsgihiilrte

    Sequence, based on observed residues (ATOM records): (download) 
    >3tc5A (A:)
lppgwekamsrssgrvyyfnhitnasqwerpeparvrcshllvkhsqsrrpsswrqekit
rtkeealelingyiqkiksgeedfeslasqfsdcssakargdlgafsrgqmqkpfedasf
alrtgemsgpvftdsgihiilrte