PDB entry 3t2n
View 3t2n on RCSB PDB site
Description: Human hepsin protease in complex with the Fab fragment of an inhibitory antibody
Class: hydrolase
Keywords: Type II transmembrane serine protease, SRCR domain, Substrates include pro-hepsin, pro-HGF, Laminin-332, Transmembrane, HYDROLASE
Deposited on
2011-07-22, released
2011-12-28
The last revision prior to the SCOPe 2.06 freeze date was dated
2012-07-25, with a file datestamp of
2012-07-20.
Experiment type: XRAY
Resolution: 2.55 Å
R-factor: 0.244
AEROSPACI score: 0.26
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Serine protease hepsin
Species: Homo sapiens [TaxId:9606]
Gene: HPN, TMPRSS1
Database cross-references and differences (RAF-indexed):
- Chain 'B':
Compound: Serine protease hepsin
Species: Homo sapiens [TaxId:9606]
Gene: HPN, TMPRSS1
Database cross-references and differences (RAF-indexed):
- Chain 'H':
Compound: Antibody, Fab fragment, Heavy Chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Chain 'I':
Compound: Antibody, Fab fragment, Heavy Chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Chain 'L':
Compound: Antibody, Fab fragment, Light Chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d3t2nl1, d3t2nl2 - Chain 'M':
Compound: Antibody, Fab fragment, Light Chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d3t2nm1, d3t2nm2 - Heterogens: HOH
PDB Chain Sequences:
- Chain 'A':
No sequence available.
- Chain 'B':
No sequence available.
- Chain 'H':
No sequence available.
- Chain 'I':
No sequence available.
- Chain 'L':
Sequence, based on SEQRES records: (download)
>3t2nL (L:)
qtvvtqepsltvspggtvtltcrsstgavttsnyanwvqqkpgqafrgligdtnnrapwt
parfsgsllggkaaltlsgvqpedeaeyycalwysnhfifgsgtkvtvlgqpkaapsvtl
fppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassy
lsltpeqwkshrsyscqvthegstvektvaptecs
Sequence, based on observed residues (ATOM records): (download)
>3t2nL (L:)
qtvvtqepsltvspggtvtltcrsstgavttsnyanwvqqkpgqafrgligdtnnrapwt
parfsgsllggkaaltlsgvqpedeaeyycalwysnhfifgsgtkvtvlgqpkaapsvtl
fppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassy
lsltpeqwkshrsyscqvthegstvektvap
- Chain 'M':
Sequence, based on SEQRES records: (download)
>3t2nM (M:)
qtvvtqepsltvspggtvtltcrsstgavttsnyanwvqqkpgqafrgligdtnnrapwt
parfsgsllggkaaltlsgvqpedeaeyycalwysnhfifgsgtkvtvlgqpkaapsvtl
fppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassy
lsltpeqwkshrsyscqvthegstvektvaptecs
Sequence, based on observed residues (ATOM records): (download)
>3t2nM (M:)
qtvvtqepsltvspggtvtltcrsstgavttsnyanwvqqkpgqafrgligdtnnrapwt
parfsgsllggkaaltlsgvqpedeaeyycalwysnhfifgsgtkvtvlgqpkaapsvtl
fppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassy
lsltpeqwkshrsyscqvthegstvektvapt