PDB entry 3t06

View 3t06 on RCSB PDB site
Description: Crystal Structure of the DH/PH fragment of PDZRHOGEF with N-terminal regulatory elements in complex with Human RhoA
Class: signaling protein
Keywords: DH-PH RhoA complex, PDZRhoGEF, GUANINE NUCLEOTIDE EXCHANGE FACTOR, RhoA, SIGNALING PROTEIN
Deposited on 2011-07-19, released 2011-08-03
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-11-08, with a file datestamp of 2017-11-03.
Experiment type: XRAY
Resolution: 2.84 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Rho guanine nucleotide exchange factor 11
    Species: Homo sapiens [TaxId:9606]
    Gene: ARHGEF11, KIAA0380
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3t06a1, d3t06a2
  • Chain 'B':
    Compound: transforming protein rhoa
    Species: Homo sapiens [TaxId:9606]
    Gene: ARH12, ARHA, RHO12, RHOA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61586 (0-177)
      • engineered mutation (22)
    Domains in SCOPe 2.07: d3t06b_
  • Chain 'E':
    Compound: Rho guanine nucleotide exchange factor 11
    Species: Homo sapiens [TaxId:9606]
    Gene: ARHGEF11, KIAA0380
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3t06e1, d3t06e2
  • Chain 'F':
    Compound: transforming protein rhoa
    Species: Homo sapiens [TaxId:9606]
    Gene: ARH12, ARHA, RHO12, RHOA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61586 (0-177)
      • engineered mutation (22)
    Domains in SCOPe 2.07: d3t06f_

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3t06A (A:)
tpkmgrrsiespslgfctdtllphlleddlgqlsdlepepdaqnwqhtvgkdvvagltqr
eidrqevinelfvteashlrtlrvldlifyqrmkkenlmpreelarlfpnlpelieihns
wceamkklreegpiikeisdlmlarfdgpareelqqvaaqfcsyqsialeliktkqrkes
rfqlfmqeaeshpqcrrlqlrdliisemqrltkyplllesiikhteggtseheklcrard
qcreilkyvneavkqtenrhrlegyqkrldatalerasnplaaefksldlttrkmihegp
ltwriskdktldlhvllledllvllqkqdeklllkchsktavgssdskqtfspvlklnav
lirsvatdkraffiictsklgppqiyelvaltssdkntwmelleeavrnahhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3t06A (A:)
qnwqhtvgkdvvagltqreidrqevinelfvteashlrtlrvldlifyqrmkkenlmpre
elarlfpnlpelieihnswceamkklreegpiikeisdlmlarfdgpareelqqvaaqfc
syqsialeliktkqrkesrfqlfmqeaeshpqcrrlqlrdliisemqrltkyplllesii
khteggtseheklcrardqcreilkyvneavkqtenrhrlegyqkrldatalerasnpla
aefksldlttrkmihegpltwriskdktldlhvllledllvllqkqdeklllkctfspvl
klnavlirsvatdkraffiictsklgppqiyelvaltssdkntwmelleeavrna

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3t06B (B:)
airkklvivgdgacgktcllivnskdqfpevyvptvfenyvadievdgkqvelalwdtag
qedydrlrplsypdtdvilmcfsidspdslenipekwtpevkhfcpnvpiilvgnkkdlr
ndehtrrelakmkqepvkpeegrdmanrigafgymecsaktkdgvrevfematraalq

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >3t06E (E:)
tpkmgrrsiespslgfctdtllphlleddlgqlsdlepepdaqnwqhtvgkdvvagltqr
eidrqevinelfvteashlrtlrvldlifyqrmkkenlmpreelarlfpnlpelieihns
wceamkklreegpiikeisdlmlarfdgpareelqqvaaqfcsyqsialeliktkqrkes
rfqlfmqeaeshpqcrrlqlrdliisemqrltkyplllesiikhteggtseheklcrard
qcreilkyvneavkqtenrhrlegyqkrldatalerasnplaaefksldlttrkmihegp
ltwriskdktldlhvllledllvllqkqdeklllkchsktavgssdskqtfspvlklnav
lirsvatdkraffiictsklgppqiyelvaltssdkntwmelleeavrnahhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3t06E (E:)
qnwqhtvgkdvvagltqreidrqevinelfvteashlrtlrvldlifyqrmkkenlmpre
elarlfpnlpelieihnswceamkklreegpiikeisdlmlarfdgpareelqqvaaqfc
syqsialeliktkqrkesrfqlfmqeaeshpqcrrlqlrdliisemqrltkyplllesii
khteggtseheklcrardqcreilkyvneavkqtenrhrlegyqkrldatalerasnpla
aefksldlttrkmihegpltwriskdktldlhvllledllvllqkqdeklllkchsktfs
pvlklnavlirsvatdkraffiictsklgppqiyelvaltssdkntwmelleeavrna

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3t06F (F:)
airkklvivgdgacgktcllivnskdqfpevyvptvfenyvadievdgkqvelalwdtag
qedydrlrplsypdtdvilmcfsidspdslenipekwtpevkhfcpnvpiilvgnkkdlr
ndehtrrelakmkqepvkpeegrdmanrigafgymecsaktkdgvrevfematraalq