SCOPe 2.05: Structural Classification of Proteins

PDB entry 3sz9

View 3sz9 on RCSB PDB site
Description: Crystal structure of human ALDH2 modified with the beta-elimination product of Aldi-3; 1-(4-ethylbenzene)prop-2-en-1-one
Class: oxidoreductase/oxidoreductase inhibitor
Keywords: ALDH, Aldi-3, inhibitor, Rossmann Fold, Oxidoreductase, Covalent adduct, Mitochondria, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Deposited on 2011-07-18, released 2011-11-02
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-12-28, with a file datestamp of 2011-12-23.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.176
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: aldehyde dehydrogenase, mitochondrial
Species: Homo sapiens [TaxId:9606]
Gene: ALDH2, ALDM
Database cross-references and differences (RAF-indexed):
- Uniprot P05091 (Start-499)
Domains in SCOPe 2.05: d3sz9a_
Chain 'B':
Compound: aldehyde dehydrogenase, mitochondrial
Species: Homo sapiens [TaxId:9606]
Gene: ALDH2, ALDM
Database cross-references and differences (RAF-indexed):
- Uniprot P05091 (Start-499)
Domains in SCOPe 2.05: d3sz9b_
Chain 'C':
Compound: aldehyde dehydrogenase, mitochondrial
Species: Homo sapiens [TaxId:9606]
Gene: ALDH2, ALDM
Database cross-references and differences (RAF-indexed):
- Uniprot P05091 (Start-499)
Domains in SCOPe 2.05: d3sz9c_
Chain 'D':
Compound: aldehyde dehydrogenase, mitochondrial
Species: Homo sapiens [TaxId:9606]
Gene: ALDH2, ALDM
Database cross-references and differences (RAF-indexed):
- Uniprot P05091 (Start-499)
Domains in SCOPe 2.05: d3sz9d_
Chain 'E':
Compound: aldehyde dehydrogenase, mitochondrial
Species: Homo sapiens [TaxId:9606]
Gene: ALDH2, ALDM
Database cross-references and differences (RAF-indexed):
- Uniprot P05091 (Start-499)
Domains in SCOPe 2.05: d3sz9e_
Chain 'F':
Compound: aldehyde dehydrogenase, mitochondrial
Species: Homo sapiens [TaxId:9606]
Gene: ALDH2, ALDM
Database cross-references and differences (RAF-indexed):
- Uniprot P05091 (Start-499)
Domains in SCOPe 2.05: d3sz9f_
Chain 'G':
Compound: aldehyde dehydrogenase, mitochondrial
Species: Homo sapiens [TaxId:9606]
Gene: ALDH2, ALDM
Database cross-references and differences (RAF-indexed):
- Uniprot P05091 (Start-499)
Domains in SCOPe 2.05: d3sz9g_
Chain 'H':
Compound: aldehyde dehydrogenase, mitochondrial
Species: Homo sapiens [TaxId:9606]
Gene: ALDH2, ALDM
Database cross-references and differences (RAF-indexed):
- Uniprot P05091 (Start-499)
Domains in SCOPe 2.05: d3sz9h_
Heterogens: NA, GAI, EDO, I3E, HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>3sz9A (A:)
saaatqavpapnqqpevfcnqifinnewhdavsrktfptvnpstgevicqvaegdkedvd
kavkaaraafqlgspwrrmdashrgrllnrladlierdrtylaaletldngkpyvisylv
dldmvlkclryyagwadkyhgktipidgdffsytrhepvgvcgqiipwnfpllmqawklg
palatgnvvvmkvaeqtpltalyvanlikeagfppgvvnivpgfgptagaaiashedvdk
vaftgsteigrviqvaagssnlkrvtlelggkspniimsdadmdwaveqahfalffnqgq
cccagsrtfvqediydefversvaraksrvvgnpfdskteqgpqvdetqfkkilgyintg
kqegakllcgggiaadrgyfiqptvfgdvqdgmtiakeeifgpvmqilkfktieevvgra
nnstyglaaavftkdldkanylsqalqagtvwvncydvfgaqspfggykmsgsgrelgey
glqaytevktvtvkvpqkns